MI-3 (Menin-MLL Inhibitor)
-
MI-3 (Menin-MLL Inhibitor)
structure -
-
CAS No:
1271738-59-0
-
Formula:
C18H25N5S2
-
Chemical Name:
MI-3 (Menin-MLL Inhibitor)
-
Synonyms:
MI-3;Menin-MLL inhibitor 3;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine;MI-3 (Menin-MLL Inhibitor);4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidineMI-3
- Categories:
-
CAS No:
Description
MI-3 is a Menin-MLL interaction inhibitor with IC50 value of 648 ± 25 nM.IC50 value: 648 ± 25 nM [1]Target: Menin-MLLin vitro: The menin-MLL inhibitors very effectively blocked proliferation of MLL-AF9 and MLL-ENL transduced BMC, with GI50 values of about 5 μM for MI-2 and MI-3. MI-2 and MI-3 showed only a small effect on the cell growth of E2A-HLF transduced BMC (GI50 > 50 μM). MI-2 and MI-3 substantially and specifically reduce the immortalization potential of cells transformed with ML
Characteristics
98.16000
3.23
1.36±0.1 g/cm3(Predicted)
527.9±60.0 °C(Predicted)
273.1±32.9 °C
1.713
H2O: Insuluble (4.5E-3 g/L) (25 ºC)
Recommended Suppliers of MI-3 (Menin-MLL Inhibitor)
-
![United States]()
US
6 YRS
Business licensed Certified factoryManufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates
Latest News on MI-3 (Menin-MLL Inhibitor)
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
MI-2 (Menin-MLL Inhibitor)
1271738-62-5
-
MS 3 (enzyme inhibitor)
58265-74-0
-
Dabrafenib
1195765-45-7
-
BOC-VAL-VAL-OH Formula
69209-73-0
-
BMS 303141 Formula
943962-47-8
-
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanamide Formula
60117-17-1
-
(2S)-2-acetamido-6-amino-N-[(2S)-2-amino-3-methylbutanoyl]-N-propylhexanamide Structure
57899-96-4
-
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea Structure
26130-02-9
-
What is L-Tyrosyl-L-phenylalanine
17355-11-2
-
What is C-REACTIVE PROTEIN FRAGMENT 77-82
130349-01-8