Desvenlafaxine succinate Monohydrate
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Desvenlafaxine succinate Monohydrate
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CAS No:
386750-22-7
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Formula:
C20H31NO6
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Chemical Name:
Desvenlafaxine succinate Monohydrate
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Synonyms:
Desvenlafaxine succinate;4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate hydrate;4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate monohydrate;2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium3-carboxypropanoatemonohydrate;Desvenlafaxine succinate monohydrate;Pristiq;Unii-zb22enf0xr;Desvenlafaxine (succinate hydrate)
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CAS No:
Description
Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
Desvenlafaxine Succinate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that was approved for the treatment of major depressive disorder (MDD) in the United States in 2008. In order to improve the efficacy and safety profile of venlafaxine, Wyeth discovered and developed one of the major metabolites of venlafaxine, namely the O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is also being developed for the treatment of moderate to severe vasomotor symptoms associated with menopause (i.e., hot flashes and night sweats) and is also in phase III clinical trials to study it’s effectiveness in treating fibromyalgia and neuropathic pain.
Desvenlafaxine succinate (Pristiq SR) is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for treating MDD. Desvenlafaxine succinate is a white to off-white powder that is soluble in water. The solubility of Desvenlafaxine succinate is pH-dependent. Its octanol: aqueous system (at pH 7.0) partition coefficient is 0.21. Desvenlafaxine succinate (Pristiq SR) is available as a 50 mg extended-release tablet for oral administration. The 50 mg tablet consists of light pink, square (pyramid, one-sided), film-coated tablets debossed “W” over “50” on the flat side.
Characteristics
119
2.66840
White crystalline powde
403.8ºC at 760 mmHg
193.2ºC
Store at +4°C
Store at +4°C
Safety Information
WGK 3
P201, P202, P260, P263, P264, P270, P273, P280, P281, P305+P351+P338, P308+P313, P337+P313, P391, P405, P501
H319
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Desvenlafaxine succinate Monohydrate
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