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Y27632 (hydrochloride)

Y27632 (hydrochloride) structure

CAS No:
129830-38-2
Formula:
C14H21N3O.2(HCl)
Chemical Name:
Y27632 (hydrochloride)
Synonyms:
Y27632 (hydrochloride);(+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride;trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride;Y27632 HCl;Y-27632, Dihydrochloride Salt, >99%;trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochlorideY 27632 dihydrochloride;Y 27632 dihydrochloride (+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride;Y-27632 dihydrochloride, >=98%
Categories:
Biochemical Engineering > Inhibitors

Description

Y-27632 dihydrochloride is a cell-permeable, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively.

Y27632 (hydrochloride) Basic Attributes

Molecular Weight：

320.258

Exact Mass：

319.121826

EC Number：

-0

UNII：

Q9828II7F3

DSSTox ID：

DTXSID3042635

HScode：

29333990

Characteristics

PSA：

Appearance：

white to beige

Melting Point：

258℃

Water Solubility：

H2O: soluble14mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

Marks：

Precautionary statement(s)：

P261-P280-P301 + P312 + P330

Hazard Statements：

H302 + H312 + H332

GHS Classification：

|Warning|H302+H312+H332 (33.33%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

MeSH Entry Terms：

N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide

Y27632 (hydrochloride) Use and Manufacturing

A cell permeable inhibitor of ROCK-1 and ROCK-2

Computed Properties

Molecular Weight:320.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:319.1218178
Monoisotopic Mass:319.1218178
Topological Polar Surface Area:68
Heavy Atom Count:20
Complexity:268
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Y27632 (hydrochloride)

CAS No.: 129830-38-2

Content: 99.00%

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