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Vinflunine Tartrate

Vinflunine Tartrate structure

CAS No:
1201898-17-0
Formula:
C45H54F2N4O8.xC4H6O6
Chemical Name:
Vinflunine Tartrate
Synonyms:
Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19β)-, (2R,3R)-2,3-dihydroxybutanedioate (1:x)
Categories:
Biochemical Engineering > Inhibitors

Description

Vinflunine Tartrat is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.Target: Microtubule/TubulinThe major effects of Vinflunine on dynamic instability are a slowing of the microtubule growth rate, an increase in growth duration, and a reduction in shortening duration. The effects of Vinflunine on the readmilling rate is examined by following [3H]GTP incorporation into MAP-rich microtubules, and the IC50 is 0.42 μM [1].

Vinflunine Tartrate Basic Attributes

Molecular Weight：

967.0

Exact Mass：

966.40700

DSSTox ID：

DTXSID00692888

Characteristics

PSA：

248.93000

XLogP3：

2.89690

Computed Properties

Molecular Weight:967.0
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:19
Rotatable Bond Count:13
Exact Mass:966.40740892
Monoisotopic Mass:966.40740892
Topological Polar Surface Area:249
Heavy Atom Count:69
Complexity:1850
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes