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VX 765

VX 765 structure

CAS No:
273404-37-8
Formula:
C24H33ClN4O6
Chemical Name:
VX 765
Synonyms:
L-Prolinamide,N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-;N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide;VX 765;Belnacasan;851091-96-8
Categories:
Biochemical Engineering > Inhibitors

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Description

Belnacasan (VX-765) is an oral prodrug of VRT-043198, a potent and selective caspase-1 inhibitor with a Ki of 0.8 nM.

VX 765 Basic Attributes

Molecular Weight：

508.99502

Exact Mass：

508.99

UNII：

00OLE78529

Characteristics

PSA：

140

XLogP3：

2.3

Density：

1.3±0.1 g/cm3

Boiling Point：

779.0±60.0°C at 760 mmHg

Flash Point：

424.9±32.9 °C

Refractive Index：

1.589

Drug Information

MeSH Entry Terms：

1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid

VX 765 Use and Manufacturing

VX-765 shows anti-convulsant activity by inhibiting interlukin-1β biosynthesis.

Computed Properties

Molecular Weight:509.0
XLogP3:2.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:508.2088625
Monoisotopic Mass:508.2088625
Topological Polar Surface Area:140
Heavy Atom Count:35
Complexity:818
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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VX-765

CAS No.: 273404-37-8

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