Lappaconitine
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Lappaconitine
structure -
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CAS No:
32854-75-4
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Formula:
C32H44N2O8
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Chemical Name:
Lappaconitine
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Synonyms:
Aconitane-4,8,9-triol,20-ethyl-1,14,16-trimethoxy-,4-[2-(acetylamino)benzoate],(1α,14α,16β)-;Lappaconitine;2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine,aconitane-4,8,9-triol deriv.;(+)-Lappaconitine;Acetyl-10-deoxysepaconitine;Lappacontine;1358-87-8;30373-78-5;1103572-03-7;1435973-51-5;1582040-40-1;1657738-31-2;1825388-42-8
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CAS No:
Description
Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as analgesic principle.IC50 value:Target:In vitro: In vivo: Lappaconitine was characterized as analgesic principle by our laboratory. The results suggest that lappaconitine can produce analgesia, possibly through a decrease in cellular calcium availability and PAG may be involved in the Ca2+ antagonistic effect on lappaconitine analgesia [1]. Changes in lappaconitine levels in blood, brain and spinal cord followi
Characteristics
126.79000
2.13
white powder
1.4±0.1 g/cm3
226-227 °C
720.7±60.0 °C at 760 mmHg
389.7±32.9 °C
1.624
Store in original container in a cool dark place.
LD50 in mice (mg/kg): 6.9 i.v.; 9.1 i.p.; approx 20 orally (Dybing)
D18 +27° (chloroform)
Drug Information
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents). (See all compounds classified as Psychotropic Drugs.)|A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)
lappaconitine
Computed Properties
Molecular Weight:584.7
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:584.30976637
Monoisotopic Mass:584.30976637
Topological Polar Surface Area:127
Heavy Atom Count:42
Complexity:1120
Undefined Atom Stereocenter Count:12
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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