Cytochalasin C
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Cytochalasin C
structure -
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CAS No:
22144-76-9
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Formula:
C30H37NO6
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Chemical Name:
Cytochalasin C
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Synonyms:
1H-Cycloundec[d]isoindole-1,11(2H)-dione,15-(acetyloxy)-3,3a,6,6a,9,10,12,15-octahydro-6,12-dihydroxy-4,5,10,12-tetramethyl-3-(phenylmethyl)-,(3S,3aR,6S,6aR,7E,10S,12R,13E,15R,15aR)-;1H-Cycloundec[d]isoindole-1,11(2H)-dione,3-benzyl-3,3a,6,6a,9,10,12,15-octahydro-6,12,15-trihydroxy-4,5,10,12-tetramethyl-,15-acetate;[11]Cytochalasa-5,13,19-triene-1,17-dione,21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E,21R)-;1H-Cycloundec[d]isoindole,[11]cytochalasa-5,13,19-triene-1,17-dione deriv.;(3S,3aR,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,6,6a,9,10,12,15-octahydro-6,12-dihydroxy-4,5,10,12-tetramethyl-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione;Cytochalasin C;1H-Cycloundec[d]isoindole-1,11(2H)-dione,15-(acetyloxy)-3,3a,6,6a,9,10,12,15-octahydro-6,12-dihydroxy-4,5,10,12-tetramethyl-3-(phenylmethyl)-,[3S-(3R*,3aS*,6R*,6aS*,7E,10R*,12S*,13E,15S*,15aS*)]-;11044-50-1
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CAS No:
Description
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D[1][2][3].
Characteristics
112.93000
2.81
1.2±0.1 g/cm3
260-265 °C @ Solvent: Methanol
714.3±60.0 °C at 760 mmHg
385.8±32.9 °C
1.602
methylene chloride: 5 mg/mL, clear, colorless
−20°C
2.05E-21mmHg at 25°C
Safety Information
I
6.1(a)
UN 1544 6.1/PG 2
3
26/27/28-63
28-36/37-45
HA5300500
T+,T
P260-P264-P280-P284-P301 + P310-P302 + P350
H300 + H310 + H330-H361
|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P262, P264, P270, P271, P280, P281, P284, P301+P310, P302+P350, P304+P340, P308+P313, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Cytochalasin C Use and Manufacturing
Cytochalasin C is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. The cytochalasins act by disrupting actin microfilaments and these effects are most noticeable by the inhibition of cell division.
Computed Properties
Molecular Weight:507.6
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:507.26208790
Monoisotopic Mass:507.26208790
Topological Polar Surface Area:113
Heavy Atom Count:37
Complexity:1020
Undefined Atom Stereocenter Count:8
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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