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Quisqualic acid

Quisqualic acid structure

CAS No:
52809-07-1
Formula:
C5H7N3O5
Chemical Name:
Quisqualic acid
Synonyms:
1,2,4-Oxadiazolidine-2-propanoic acid,α-amino-3,5-dioxo-,(αS)-;Quisqualic acid;1,2,4-Oxadiazolidine-2-propanoic acid,α-amino-3,5-dioxo-,(S)-;(αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid;L-Quisqualic acid;S-Quisqualic acid;Quisqualinic acid;(2S)-2-Amino-3-(3-hydroxy-5-oxo-2,5-dihydro-1,2,4-oxadiazol-2-yl)propanoic acid;(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid;(2S)-2-Amino-3-(5-hydroxy-3-oxo-2,3-dihydro-1,2,4-oxadiazol-2-yl)propanoic acid;51821-59-1;52284-24-9
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

Off-White Solid

Quisqualic acid is a non-proteinogenic alpha-amino acid.|Quisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.|An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.

Quisqualic acid Basic Attributes

Molecular Weight：

189.13

Exact Mass：

189.13

UNII：

8OC22C1B99

HScode：

2934999090

Characteristics

PSA：

122

XLogP3：

-1.85

Appearance：

white to off-white

Density：

2.0±0.1 g/cm3

Melting Point：

199-202 °C @ Solvent: Ethanol

Boiling Point：

405.9±55.0 °C at 760 mmHg

Flash Point：

199.3±31.5 °C

Refractive Index：

1.726

Water Solubility：

soluble in ethanol, water. Insoluble in organic solvents.NH4OH 1 M: 20 mg/mL, clear, colorless

Storage Conditions：

2-8°C

Specific rotation：

D20 +17.0° (c = 2.0 in 6M HCl)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

26-36

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P280

Hazard Statements：

H302-H312-H332

GHS Classification：

|Warning|H302+H312+H332 (79.59%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 196 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to and activate excitatory amino acid receptors. (See all compounds classified as Excitatory Amino Acid Agonists.)

MeSH Entry Terms：

Quisqualate

Quisqualic acid Use and Manufacturing

An amino acid that is able to function as an agonist at multiple excitatory amino acidreceptor substrates in the central nervous system.It also has high affinity for the kainate, AMPA and the metabotropic receptors.Inhibits the Ca2+/Cl-dependent glutamicacid uptake system in brain synaptic plasma membrane preparations.

Computed Properties

Molecular Weight:189.13
XLogP3:-3.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:189.03857033
Monoisotopic Mass:189.03857033
Topological Polar Surface Area:122
Heavy Atom Count:13
Complexity:265
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Quisqualic acid

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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Quisqualic acid

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