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(+)-Epibatidine

(+)-Epibatidine structure

(+)-Epibatidine 

structure
  • CAS No:

    140111-52-0

  • Formula:

    C11H13ClN2

  • Chemical Name:

    (+)-Epibatidine

  • Synonyms:

    7-Azabicyclo[2.2.1]heptane,2-(6-chloro-3-pyridinyl)-,(1R,2R,4S)-;7-Azabicyclo[2.2.1]heptane,2-(6-chloro-3-pyridinyl)-,(1R-exo)-;(1R,2R,4S)-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane;Epibatidine;Alkaloid 208/210 from Dendrobates;(1R-exo)-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane;(1R,2R,4S)-Epibatidine;CMI 488;(+)-Epibatidine;152378-31-9;163437-11-4

  • Categories:

    Biochemical Engineering  >  Chinese Herbs

Description

3-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane is an alkaloid.

(+)-Epibatidine Basic Attributes

208.69

208.69

Characteristics

24.92000

2.67170

1.223±0.06 g/cm3(Predicted)

336.7±32.0 °C(Predicted)

157.4ºC

1.576

Desiccate at +4°C

0.00011mmHg at 25°C

Safety Information

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P262, P264, P270, P280, P301+P310, P302+P350, P310, P321, P322, P330, P361, P363, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)|Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission. (See all compounds classified as Nicotinic Agonists.)

epibatidine

(+)-Epibatidine Use and Manufacturing

Very potent nicotinic agonist (K i values are 0.02 and 233 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Analgesic.

Computed Properties

Molecular Weight:208.69
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:208.0767261
Monoisotopic Mass:208.0767261
Topological Polar Surface Area:24.9
Heavy Atom Count:14
Complexity:221
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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