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Silychristin

Silychristin structure

CAS No:
33889-69-9
Formula:
C25H22O10
Chemical Name:
Silychristin
Synonyms:
4H-1-Benzopyran-4-one,2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-;4H-1-Benzopyran-4-one,2-[2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-,[2R-[2α(2R*,3S*),3β]]-;4-Chromanone,2-[2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-3,5,7-trihydroxy-,(2S,3S)-(+)-;(2R,3R)-2-[(2R,3S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Silychristin;Silymarin II;Silicristin;Silycristin;Silichristin;Silychristin A;(+)-Silychristin
Categories:
Biochemical Engineering > Chinese Herbs

Description

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].

Silychristin is a flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase. It has a role as a radical scavenger, a lipoxygenase inhibitor, a prostaglandin antagonist and a metabolite. It is a flavonolignan, a member of 1-benzofurans, a polyphenol, an aromatic ether and a secondary alpha-hydroxy ketone.

Silychristin Basic Attributes

Molecular Weight：

482.44

Exact Mass：

482.44

EC Number：

251-720-9

UNII：

LK279ER14X

DSSTox ID：

DTXSID50187512

Characteristics

PSA：

166

XLogP3：

2.20

Density：

1.6±0.1 g/cm3

Melting Point：

174～176℃

Boiling Point：

782.0±60.0 °C at 760 mmHg

Flash Point：

270.5±26.4 °C

Refractive Index：

1.716

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-45

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

silicristin

Silychristin Use and Manufacturing

Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic flavonolignan.

Computed Properties

Molecular Weight:482.4
XLogP3:2.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:482.12129689
Monoisotopic Mass:482.12129689
Topological Polar Surface Area:166
Heavy Atom Count:35
Complexity:765
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 33889-69-9

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Guide of Silychristin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Silychristin

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