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Silydianin

Silydianin structure

CAS No:
29782-68-1
Formula:
C25H22O10
Chemical Name:
Silydianin
Synonyms:
3,6-Methanobenzofuran-7(6H)-one,4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-,(3R,3aR,6R,7aR,8R)-;3,6-Methanobenzofuran-7(6αH)-one,2,3α,3aα,7a-tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-,(+)-;3,6-Methanobenzofuran-7(6H)-one,4-(3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-,[3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-;(3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one;Silydianin;Silidianine;Silidianin
Categories:
Biochemical Engineering > Chinese Herbs

Description

Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3].

Silydianin Basic Attributes

Molecular Weight：

482.44

Exact Mass：

482.44

EC Number：

249-848-5

DSSTox ID：

DTXSID70858696

HScode：

2932996560

Characteristics

PSA：

162.98000

XLogP3：

1.84

Density：

1.7±0.1 g/cm3

Melting Point：

185-187 °C @ Solvent: Methanol

Boiling Point：

819.0±65.0 °C at 760 mmHg

Flash Point：

285.0±27.8 °C

Refractive Index：

1.747

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-45

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

silidianin

Silydianin Use and Manufacturing

Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.

Computed Properties

Molecular Weight:482.4
XLogP3:0.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:482.12129689
Monoisotopic Mass:482.12129689
Topological Polar Surface Area:163
Heavy Atom Count:35
Complexity:935
Defined Atom Stereocenter Count:6
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 29782-68-1

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Distributor Supplier of DIMETHYL SULFOXIDE,NMP,MMT

Silydianin(29782-68-1)

Unit Price: $1100 /KG FOB

CAS No.: 29782-68-1

Grade: industrial Grade

Content: 99.5%

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Guide of Silydianin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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