Adenanthin
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Adenanthin
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CAS No:
111917-59-0
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Formula:
C26H34O9
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Chemical Name:
Adenanthin
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Synonyms:
Adenanthin;Actinodephnine Acuminatin Acuminatoside Adenanthin
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CAS No:
Adenanthin Use and Manufacturing
This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding prote
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