Mesosulfuron-methyl

503.51

503.51

606-653-3

22L00R79A6

DTXSID6034712

Cream-colored solid

209

1.39 (pH 5)

1.53 gm/cu cm at 23 deg C

195.4°

1.591

In water (g/L at 20 deg C): 7.24X10-3 (pH 5); 0.483 (pH 7); 15.39 (pH 9)

0-6°C

1.1X10-8 mPa /SRC: 8.25X10-14 mm Hg/ at 25 deg C

LD50 in rats (mg/kg): >5000 orally; >5000 dermally; LC50 in rats: >1.33 mg/l air (Hacker)

Weakly pungent

Henry's Law constant = 1.1X10-16 atm-cu m/mol at 25 °C (est)

pKa = 4.35 at 20 °C

UN 3077

2

50

60-61

N

P273

H400

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|Pesticide Disposal. Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. /Osprey Herbicide/|Container Disposal. Empty containers should be triple rinsed (or equivalent), then offer for recycling or reconditioning; or puncture and dispose of in a sanitary landfill, or by incineration; or, if allowed by State and local authorities, by burning. If burned, stay out of smoke. /Osprey Herbicide/|Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential users/|Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it. /Residential users/

|Warning|H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Applicators and other handlers must wear: Long-sleeved shirt and long pants, socks, shoes, chemical resistant gloves such as barrier laminate, butyl rubber greater than or equal to 14 mils, nitrile rubber greater than or equal to 14 mils, or neoprene rubber greater than or equal to 14 mils, and protective eyewear (safety glasses). /Osprey Herbicide/|... Restricted entry interval (REI) of 4 hours. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated such as plants, soil or water, is coveralls, socks, shoes, chemical resistant gloves such as barrier laminate, butyl rubber greater than or equal to 14 mils, nitrile rubber greater than or equal to 14 mils, or neoprene rubber greater than or equal to 14 mils, and protective eye wear. /Osprey Herbicide/|When handlers use closed systems, enclosed cabs or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240 (d)(4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS. /Osprey Herbicide/

Suitable Extinguishing Media: Foam, dry powder, carbon dioxide (CO2), water spray. /Osprey Herbicide/|Keep out of smoke. Fight fire from upwind position. Cool closed containers/tanks exposed to fire with water spray. Do not allow run-off from fire fighting to enter drains or water courses. Firefighters should wear NIOSH approved self-contained breathing apparatus and full protective clothing. /Osprey Herbicide/

ACCIDENTAL RELEASE MEASURES. Personal Precautions - Keep unauthorized people away. Isolate hazard area. Avoid contact with spilled product or contaminated surfaces. Methods for Cleaning Up - Avoid dust formation. Sweep up or vacuum up spillage and collect in suitable container for disposal. Clean contaminated floors and objects thoroughly, observing environmental regulations. Additional Advice - Use personal protective equipment. Do not allow to enter soil, waterways or waste water canal. /Osprey Herbicide/|Do not contaminate water by cleaning of equipment or disposal of equipment washwaters. /Osprey Herbicide/|If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential users/|After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide. To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential users/

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. /Osprey Herbicide/|Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. /Osprey Herbicide/|Users should: Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. Remove clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. Remove Personal Protective Equipment immediately after handling this product. As soon as possible, wash thoroughly and change into clean clothing. /Osprey Herbicide/|Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 4 hours. /Osprey Herbicide/|For more Preventive Measures (Complete) data for Mesosulfuron-methyl (16 total), please visit the HSDB record page.

LC50 Rat inhalation >1.33 mg/L /Duration not specified/|LD50 Rat dermal >5000 mg/kg|LD50 Rat oral >5000 mg/kg

Mesosulfuron-methyl's production may result in its release to the environment through various waste streams; its use as a herbicide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a structure estimation method(2), indicates that mesosulfuron-methyl is expected to have very high mobility in soil(SRC). The pKa of mesosulfuron-methyl is 4.35(3), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of mesosulfuron-methyl from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.1X10-16 atm-cu m/mole(SRC), based upon its vapor pressure, 8.25X10-14 mm Hg(3), and water solubility, 483 mg/L(3). Mesosulfuron-methyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation of mesosulfuron-methyl is expected in soil with reported aerobic degradation products of 2-amino-4,6-dimethoxypyrimidine, 4,6-dimethoxypyrimidin-2-ylurea and mesosulfuron acid(3).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a structure estimation method(2), indicates that mesosulfuron-methyl is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.1X10-16 atm-cu m/mole(SRC), derived from its vapor pressure, 8.25X10-14 mm Hg(4), and water solubility, 483 mg/L(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of -0.48(4) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Mesosulfuron-methyl is expected to undergo hydrolysis in the environment and has reported half-lives 319, 253 and 3.5 days at pH 4, 7 and 9, respectively, at 25 °C(4). Biodegradation of mesosulfuron-methyl is expected with reported aerobic degradation products of 2-amino-4,6-dimethoxypyrimidine, 4,6-dimethoxypyrimidin-2-ylurea and mesosulfuron acid and an anaerobic product of O-desmethyl mesosulfuron(4).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), mesosulfuron-methyl, which has a vapor pressure of 8.25X10-14 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase mesosulfuron-methyl may be removed from the air by wet or dry deposition(SRC). The compound is stable to photolysis(2).

Mesosulfuron-methyl is expected to undergo hydrolysis in the environment and has reported half-lives of 319, 253 and 3.5 days at pH 4, 7 and 9, respectively, at 25 °C. Mesosulfuron-methyl is stable to photolysis(1).

An estimated BCF of 3 was calculated in fish for mesosulfuron-methyl(SRC), using a log Kow of -0.48(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of mesosulfuron-methyl can be estimated to be 11(SRC). According to a classification scheme(2), this estimated Koc value suggests that mesosulfuron-methyl is expected to have very high mobility in soil. Mesosulfuron-methyl has a reported Kfoc of 92, analyzed in 9 soils(3). The pKa of mesosulfuron-methyl is 4.35(3), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

The Henry's Law constant for mesosulfuron-methyl is estimated as 1.1X10-16 atm-cu m/mole(SRC) derived from its vapor pressure, 8.25X10-14 mm Hg(1), and water solubility, 483 mg/L(1). This Henry's Law constant indicates that mesosulfuron-methyl is expected to be essentially nonvolatile from water and moist soil surfaces(2). Mesosulfuron-methyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

Occupational exposure to mesosulfuron-methyl may occur through inhalation of dust and dermal contact with this compound at workplaces where mesosulfuron-methyl is produced or used. Use data indicate that the general population may be exposed to mesosulfuron-methyl via herbicide application on grass. (SRC)

Wistar rats were dosed orally by gavage with 1000 mg/kg of (Phenyl-U-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 27019-1; specific activity: 10.78 MBq/g; radiochemical purity:> 99% (HPLC)) in two studies. In the first study, 4 animals/sex were dosed and urine and feces were collected periodically at specified time points up to 72 hours post-dose. In the second study, 4 animals/sex were dosed and blood samples were collected from the tail vein at specified time points up to 7 days post-dose. At 72 hours post-dose, radiolabeling in particular tissue samples was determined. The feces were the predominant route of excretion with 98 to 99% of the administered dose being recovered via that route. Eighty-eight and 96% of the administered dose was recovered in the first 24 hours from the females and males, respectively. The half-lives for urine and feces excretion were 7.1 and 3.8 hours for the males and 9.9 and 3.7 hours for the females. The maximal level of radiolabeling in the blood was achieved between 2 and 4 hours post-dose. The half-life for the elimination of radiolabeling from the blood was 11.5 and 8.2 hours for the males and females, respectively. The liver was the only tissue from which radioactivity was recovered at 72 hours post-dose. The percent of the administered dose which was recovered was 0.001% for males. In the females, radioactivity was recovered from the liver of only one animal, at a level of 0.001%. Radioactivity was recovered from the blood of two males at a level of 0.001%.|Four bile-duct cannulated Wistar rats/sex were dosed with 10 mg/kg of (Phenyl-U-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 27063-1; specific activity: 1350 MBq/g; radiochemical purity: 99.9% (HPLC)) and bile samples were collected over specified time intervals up to 12 hours post-dose. By 12 hours post-dose, 7 to 9% of the administered dose was recovered from the bile. An additional 63 to 65% of the dose was recovered in the gastrointestinal tract at the end of the 12 hour period. A predominant fraction of the radiolabel was recovered in the small intestines.|Wistar rats were dosed orally by gavage with 10 mg/kg of (Phenyl-U-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 27038-0; specific activity: 2862 MBq/g; radiochemical purity: 99% (HPLC)) in two studies. In the first study, 4 animals/sex were dosed and urine and feces were collected periodically at specified time points up to 72 hours post-dose. In the second study, 4 animals/sex were dosed and blood samples were collected from the tail vein at specified time points up to 7 days post-dose. At 72 hours post-dose, radiolabeling in particular tissue samples was determined. The feces were the predominant route of excretion with 85 to 90% of the administered dose being recovered via that route. Eighty-eight and 92% of the administered dose was recovered in the first 24 hours. The half-lives for urine and feces excretion were 7.8 and 5.2 hours for the males and 8.0 and 5.0 hours for the females. The maximal level of radiolabeling in the blood was achieved between 2 and 4 hours post-dose. The half-life for the elimination of radiolabeling from the blood was 12.0 and 10.6 hours for the males and females, respectively. The liver was the predominant tissue at which radioactivity was recovered at 72 hours post-dose. The percent of the administered dose which was recovered was 0.014 and 0.013% for males and females, respectively.|Two Wistar rats/sex/group were dosed orally by gavage with a nominal 10 or 1000 mg/kg of (2-Pyrimidyl-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 26003-0, radiochemical purity: 96.9% (HPLC determination), specific activity: 4333 MBq/g; purity: 98.1%). Urine and feces samples were collected from each animal at 24 hour intervals through 7 days post-dose (only samples collected for the 1st 72 hours were analyzed). After 7 days, the animals were euthanized and the carcasses were subjected to whole-body autoradiography. The predominant route of excretion was in the feces. Eighty to 90% of the administered dose for the low dose group was recovered in the feces. This percentage increased to greater than 95% in the high dose group. The data were not adequate to determine the actual percentage of the dose which was absorbed because a biliary excretion study was not performed. There was no apparent difference between the sexes. Seventy five to 100% of the administered dose was excreted in the first 24 hours postdose. The excretion half lives for the individual animals ranged between 6.0 and 8.8 hours for urinary excretion and between 3.1 and 9.3 hours for fecal excretion with no apparent difference evident for the different dosing levels. No radiolabeling was ascertained to be in the carcass after 168 hours post-dose.|Eighteen Wistar rats/sex were dosed orally by gavage with 250 mg/kg of (Phenyl-U-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 28008-1; specific activity: 40.33 MBq/g; radiochemical purity: >98% (HPLC)). Three animals/sex received one dose and were euthanized at 3 hours post-dose. Another 3 animals/sex received 4 daily doses and were then euthanized at 3 hours post-final dose. The remaining 12 animals/sex received 7 daily doses and 3 animals/sex/time point were euthanized at 3, 24, 48 and 168 hours post-final dose. Urine and feces were collected at specified time intervals for each group. Particular tissues were dissected from the animals in each of the groups and analyzed for the presence of radiolabeled compound. Ten to 15% of the total administered radiolabel was excreted in the feces daily during the 7 day dosing period. Recovery in the urine ranged from 0.17 to 0.33% of the total administered dose for the males and from 0.28 to 0.98% for the females during the same time period. These results indicated that a steady-state in the excretion profile had been achieved. Ninety-seven and ninety three percent of the total administered dose was recovered in the feces of the males and females, respectively, by the end of the 168 hour collection period. Two and 4.5% of the dose was recovered in the urine of the males and females, respectively. Recovery of the radiolabel in the tissues diminished perceptively as the number of daily doses increased from 1 to 4 to 7. By 168 hours post-final dose, the presence of the radiolabel in the tissues was negligible. The elimination half-lives from the blood and plasma as determined between 144 and 192 hours of the study were 13.1 and 13.3 hours for the males, respectively, and 9.9 and 9.4 hours for the females, respectively.

Wistar rats of both sexes were dosed orally by gavage with 10 mg/kg of either [Phenyl-U-14C] AE F130060 (batch no. Z 27038-0; specific activity: 2862 MBq/g; radiochemical purity: 99% (HPLC) or [Phenyl-U-14C] AE F130060 (batch no. Z 27063-1; specific activity: 1350 MBq/g; radiochemical purity: 99.9% (HPLC). For the animals treated with the former compound, urine and feces were collected at specified time intervals up to 72 hours post-dose (report no. C006348, vol no. 52970-0083, record no. 211259). For the animals treated with the latter compound, bile samples were collected for specified time intervals up to 12 hours post-dose (report no. C006349, vol. no. 52970-0084, rec. no. 211260). In this study, identification and quanitfication of the metabolites in these samples was undertaken. Pooled urine and bile samples were directly analyzed by radio-HPLC or TLC. The homogenized fecal samples were centrifuged and the supernatant water phase analyzed by HPLC. The residue was extracted using water:acetonitrile (1:4) and the samples were concentrated by rotary evaporation and analyzed by HPLC or TLC. Structures of particular metabolites were confirmed by HPLC/MS/MS. Ninety to 95% of the administered dose was recovered as the parent compound. The metabolic pathways included the cleavage of the sulfonylurea bridge, O-demethylation of the pyrimidine ring and cleavage of the methanesulfon-amidomethyl side chain.|Two Wistar rats/sex/group were dosed orally by gavage with a nominal 10 or 1000 mg/kg of [2- Pyrimidyl-14C] AE F130060 (batch no. Z 26003-0, radiochemical purity: 96.9% (HPLC determination), specific activity: (low dose) 478.95 MBq/g, (high dose) 5.05 MBq/g). Urine and feces samples were collected from each animal at 24 hour intervals through 7 days post-dose (only samples collected for the 1st 72 hours were analyzed) (see report no. C006347 (vol. 52970- 0081, record no. 211256)). In this study, the radiolabeled compounds in the urine and feces were isolated and identified. The predominant radiolabeled material which was recovered in either the urine or the feces was the unmetabolized parent compound (75 to 87% of the administered dose for either dosing regimen. Cleavage of the sulfonylurea-bridge was one of the main pathways of metabolism (AE F092944) as noted in the fecal metabolites. Other paths of metabolism included O-demethylation on the pyrimidine (AE F160459) and cleavage of the methanesulfonamidomethyl side chain (AE F151015, AE 0195141). One metabolite (AE F118772) resulted from the combined cleavage of the sulfonylurea bridge and O-demethylation of the pyrimidine.|Wistar rats of both sexes were dosed orally by gavage with 1000 mg/kg of [Phenyl-U-14C] AE F130060 (batch no. Z 27019-1; specific activity: 10.78 MBq/g; radiochemical purity:> 99% (HPLC)). Urine and feces were collected at specified time intervals up to 72 hours post-dose (report no. A67074, vol no. 52970-0086, record no. 211262). In this study, identification and quanitfication of the metabolites in these samples was undertaken. Pooled urine and bile samples were directly analyzed by radio-HPLC or TLC. The homogenized fecal samples were centrifuged and the supernatant water phase analyzed by HPLC. The residue was extracted using water:acetonitrile (1:4) and the samples were concentrated by rotary evaporation and analyzed by HPLC or TLC. Structures of particular metabolites were confirmed by HPLC/MS/MS. Eighty one to 89% of the administered dose was recovered as the parent compound. The metabolic pathway included the cleavage of the sulfonylurea bridge, Odemethylation of the pyrimidine ring and cleavage of the methanesulfon-amidomethyl side chain.|18 Wistar rats/sex were dosed orally by gavage with 250 mg/kg of [Phenyl-U-14C] AE F130060 (batch no. Z 28008-1; specific activity: 40.33 MBq/g; radiochemical purity: >98% (HPLC)) (report no. C006350, vol. 52970-0088, 211264). Three animals/sex received one dose and were euthanized at 3 hours post-dose. Another 3 animals/sex received 4 daily doses and were then euthanized at 3 hours post-final dose. The remaining 12 animals/sex received 7 daily doses and 3 animals/sex/time point were euthanized at 3, 24, 48 and 168 hours post-final dose. Urine and feces were collected at specified time intervals for each group. The radiolabeled compounds recovered from pooled urine and fecal samples from some of these animals were identified and quantified by HPLC and TLC. After one dose of 250 mg/kg, 79 to 86% of the administered dose was recovered in the feces as unmetabolized parent compound up to 24 hours post-dose. Another 1 to 2% of the unmetabolized compound was recovered in the urine over this time period. After 7 doses, 95 to 99% of the radiolabeled compound which was recovered in the feces up to 48 hours post-final dose was unmetabolized parent compound. The percentage of total administered dose which was recovered in the feces over this time period was 15 to 16%. The metabolic pathways included the cleavage of the sulfonylurea bridge, O-demethylation of the pyrimidine ring and cleavage of the methanesulfon-amidomethyl side chain.

Wistar rats were dosed orally by gavage with 1000 mg/kg of (Phenyl-U-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 27019-1; specific activity: 10.78 MBq/g; radiochemical purity:> 99% (HPLC)) in two studies. In the first study, 4 animals/sex were dosed and urine and feces were collected periodically at specified time points up to 72 hours post-dose. In the second study, 4 animals/sex were dosed and blood samples were collected from the tail vein at specified time points up to 7 days post-dose. ... The half-life for the elimination of radiolabeling from the blood was 11.5 and 8.2 hours for the males and females, respectively.|Two Wistar rats/sex/group were dosed orally by gavage with a nominal 10 or 1000 mg/kg of (2-Pyrimidyl-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 26003-0, radiochemical purity: 96.9% (HPLC determination), specific activity: 4333 MBq/g; purity: 98.1%). Urine and feces samples were collected from each animal at 24 hour intervals through 7 days post-dose (only samples collected for the 1st 72 hours were analyzed). ... The excretion half lives for the individual animals ranged between 6.0 and 8.8 hours for urinary excretion and between 3.1 and 9.3 hours for fecal excretion with no apparent difference evident for the different dosing levels. ...|Eighteen Wistar rats/sex were dosed orally by gavage with 250 mg/kg of (Phenyl-U-(14)C) AE F130060 (/mesosulfuron-methyl/ batch no. Z 28008-1; specific activity: 40.33 MBq/g; radiochemical purity: >98% (HPLC)). Three animals/sex received one dose and were euthanized at 3 hours post-dose. Another 3 animals/sex received 4 daily doses and were then euthanized at 3 hours post-final dose. The remaining 12 animals/sex received 7 daily doses and 3 animals/sex/time point were euthanized at 3, 24, 48 and 168 hours post-final dose. ... The elimination half-lives from the blood and plasma as determined between 144 and 192 hours of the study were 13.1 and 13.3 hours for the males, respectively, and 9.9 and 9.4 hours for the females, respectively.

Mesosulfuron-methyl belongs to the class of chemicals called sulfonyl ureas. The chemical works by inhibiting the enzyme acetolactate synthase (ALS), which leads to depletion of key amino acids that are necessary for protein synthesis and plant growth.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

AE F130060 00

Oil dispersion; water dispersible granule.|PREMIX PARTNERS: Iodosulfuron-methyl-sodium; Propoxycarbazone-sodium|Silverado Wild Oat Herbicide (Bayer Cropscience LP.) 2% Mesosulfuron-methyl|Osprey Herbicide (Bayer Cropscience LP.) 4.5% Mesosulfuron-methyl|For more Formulations/Preparations (Complete) data for Mesosulfuron-methyl (10 total), please visit the HSDB record page.

Determination of residues in water is by hplc/uv ... Residues of sulfonylureas in soil and water may also be determined by immunoassay.

Herbicides|Environmental transformation -> Pesticides (parent, predecessor)

Mesosulfuron-methyl has known environmental transformation products that include 2-amino-4,6-dimethoxypyrimidine, 4,6-dimethoxypyrimidine-2-yl-urea, and mesosulfuron.|Mesosulfuron has known environmental transformation products that include BCS-AA25052 (AE F092944), BCS-AB40283 (AE F099095), Benzisothiazole (AE F147447), Ester Sulfonamide (AE F140584), Mesosulfuron acid (AE F154851), Mesosulfuron-methyl-des-methyl-guanidine (BCS-CV14885), O-desmethyl Mesosulfuron (AE F160459), and O-desmethyl Mesosulfuron acid (AE F160460).