2-Hydroxy-N-methyl-N-phenylacetamide

The preparation method is to add chloroacetic acid, toluene, and phosphorus oxychloride to the reaction kettle in sequence, heat to a certain temperature, add N-methylaniline dropwise within a specified time, keep the temperature for several hours after the dropwise addition, and cool and wash until it is neutral , Decompression and desolvation to obtain N-methyl chloroacetanilide, then add chloroacetanilide, methanol and sodium acetate into another reactor, stir, and heat to a certain temperature, react for several hours, wash with water after the reaction, the organic layer Atmospheric pressure removal of methanol to obtain acetanilide acetate. The product, liquid caustic soda, and water are sequentially added to the reaction kettle, and the temperature is raised to a certain temperature to carry out a hydrolysis reaction, the reaction crystallization is separated, the organic layer is put into the crystallization kettle, and the product is cooled and crystallized.

N-methylhydroxyacetanilide is an intermediate of the herbicide phenothichlor.

Molecular Weight:165.19
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:165.078978594
Monoisotopic Mass:165.078978594
Topological Polar Surface Area:40.5
Heavy Atom Count:12
Complexity:153
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes