Benzoic acid, 2-(chloromethyl)-, methyl ester

The preparation method is to add o-methylbenzoyl chloride into a chlorination kettle, heat up to 90°C, and pass in chlorine gas for about 5 hours. Use gas chromatography to track and analyze and control the chlorine gas flow. When the by-product o-dichloromethyl benzoyl chloride reaches 0.8%, stop the chlorine gas flow, cool to room temperature, and transfer to a distillation pot for distillation to obtain o-chloromethyl benzoyl chloride. Further add o-chloromethyl benzoyl chloride into the esterification kettle, add quantitative methanol to heat, reflux for about 3 h, sample and analyze qualified, distill, first distill the methanol, and then distill under reduced pressure to obtain methyl o-chloromethyl benzoate . It can also be chlorinated with methyl o-methylbenzoate in the presence of a catalyst, and the reaction temperature is 65-80°C.

Methyl o-chloromethylbenzoate is an intermediate of the herbicide bensulfuron-methyl.

Molecular Weight:184.62
XLogP3:2.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:184.0291072
Monoisotopic Mass:184.0291072
Topological Polar Surface Area:26.3
Heavy Atom Count:12
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes