γ-Mangostin
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γ-Mangostin
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CAS No:
31271-07-5
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Formula:
C23H24O6
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Chemical Name:
γ-Mangostin
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Synonyms:
9H-Xanthen-9-one,1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-;9H-Xanthen-9-one,1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-;Xanthen-9-one,1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-;Mangostin,demethyl-;1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one;γ-Mangostin;Normangostin;1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone;7-O-Demethyl-α-mangostin;1,3,6,7-Tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
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CAS No:
Description
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC5
Solid
Gamma-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity. It has a role as an antineoplastic agent, a protein kinase inhibitor and a plant metabolite. It is a member of xanthones and a member of phenols.
Characteristics
107
5.14
off-white to yellow
1.3±0.1 g/cm3
206-208 °C
648.4±55.0 °C at 760 mmHg
226.4±25.0 °C
1.656
methanol: soluble1mg/mL, colorless to yellow
2-8°C
γ-Mangostin Use and Manufacturing
Gamma-mangostin has antioxidant, anti-inflammatory, antibacterial, anti-cancer and other pharmacological activities, and is widely used in medicine γ-Mangostin has anti-inflammatory, anti-oxidant, anti-allergic and bactericidal effects .
Computed Properties
Molecular Weight:396.4
XLogP3:5.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:396.15728848
Monoisotopic Mass:396.15728848
Topological Polar Surface Area:107
Heavy Atom Count:29
Complexity:662
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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