ISORHYNCHOPHYLLINE

Isorhynchophylline (IRN), an alkaloid isolated from Uncaria rhynchophylla, possesses the effects of lowered blood pressure, vasodilatation and protection against ischemia-induced neuronal damage.IC50 value:Target:In vitro: Isorhynchophylline concentration-dependently inhibited the platelet-derived growth factor (PDGF)-BB-induced proliferation of PASMCs. Fluorescence-activated cell-sorting analysis showed that isorhynchophylline caused G0/G1 phase cell cycle arrest [2]. Isorhynchophylline

Isorhynchophylline is a member of indolizines. It has a role as a metabolite.

This amorphous base has been isolated from Ourouparia rhyncophylla Mats. It has [α]29Db + 8.3° and yields a crystalline perchlorate, m.p. 150°C (dec.).

White crystalline powder, soluble in chloroform, derived from Uncaria rhynchophylla.

ChEBI: A natural product found in Uncaria macrophylla.

Isorhynchophylline is an oxindole alkaloid which has been the main active ingredient of Uncaria rhynchophylla contributing to anti-depressant like behavior in subjects.

Molecular Weight:384.5
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:384.20490738
Monoisotopic Mass:384.20490738
Topological Polar Surface Area:67.9
Heavy Atom Count:28
Complexity:663
Defined Atom Stereocenter Count:4
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes