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(+)-Glaucine

(+)-Glaucine structure

CAS No:
475-81-0
Formula:
C21H25NO4
Chemical Name:
(+)-Glaucine
Synonyms:
4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-,(6aS)-;Glaucine;6aα-Aporphine,1,2,9,10-tetramethoxy-;4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-,(S)-;(6aS)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline;d-Glaucine;(+)-Glaucine;Boldine dimethyl ether;Bromcholitin;Glauvent;S-(+)-Glaucine;O,O-Dimethylisoboldine;(S)-Glaucine;O,O-Dimethylboldine;N,O,O′-Trimethyllaurelliptine;NSC 34396;(6AS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Categories:
Natural Products > Alkaloids

Description

(S)-glaucine is an aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. It has a role as a platelet aggregation inhibitor, a NF-kappaB inhibitor, an antitussive, an antibacterial agent, a muscle relaxant, an antineoplastic agent, a plant metabolite and a rat metabolite. It is an aporphine alkaloid, a polyether, an organic heterotetracyclic compound and a tertiary amino compound. It is a conjugate base of a (S)-glaucine(1+).

(+)-Glaucine Basic Attributes

Molecular Weight：

355.43

Exact Mass：

355.43

EC Number：

207-501-5

UNII：

NU19306XA7

NSC Number：

34396

DSSTox ID：

DTXSID8031100

HScode：

2933990090

Characteristics

PSA：

40.2

XLogP3：

3.86

Density：

1.2±0.1 g/cm3

Melting Point：

124-125 °C

Boiling Point：

487.0±45.0 °C at 760 mmHg

Flash Point：

140.2±25.9 °C

Refractive Index：

1.576

Vapor Pressure：

1.23E-09mmHg at 25°C

Specific rotation：

D20 +115° (c = 3 in alc)

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

Drug Information

MeSH：

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)|Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

glaucine

Computed Properties

Molecular Weight:355.4
XLogP3:3.4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:355.17835828
Monoisotopic Mass:355.17835828
Topological Polar Surface Area:40.2
Heavy Atom Count:26
Complexity:489
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of (+)-Glaucine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Learn More Other Chemicals

(+)-Glaucine

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