Isopropyl(4-chlorophenyl)acetyl chloride

The preparation methods are as follows. In the phosgene method, put 3-methyl-2-(4-chlorophenyl) butyric acid solid into the reactor, a small amount of DMF is used as the catalyst, after the temperature is raised to the solid melting, a small amount of phosgene is introduced, and the temperature is controlled at 80~ At 90°C, gradually increase the phosgene intake. When the phosgene intake reaches a certain amount, reduce the reaction temperature to 50-60°C, and then add phosgene. When the phosgene reaches the required amount, stop the phosgene , Pass nitrogen to drive phosgene at 60～70℃, and discharge after phosgene is exhausted, which is finished product. Thionyl chloride method: Put thionyl chloride into the reactor, raise the temperature to 30～40℃, add dropwise the molten 3-methyl-2-(4-chlorophenyl) butyric acid, and after the dropwise addition is completed, at 30 Keep the temperature at ~40°C for 0.5h, after the reaction, remove excess thionyl chloride under reduced pressure, cool and discharge the finished product.

Pesticide intermediates.

Molecular Weight:231.11
XLogP3:4.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:230.0265204
Monoisotopic Mass:230.0265204
Topological Polar Surface Area:17.1
Heavy Atom Count:14
Complexity:196
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes