Prosapogenin A
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Prosapogenin A
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CAS No:
19057-67-1
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Formula:
C39H62O12
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Chemical Name:
Prosapogenin A
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Synonyms:
β-D-Glucopyranoside,(3β,25R)-spirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-;Spirost-5-ene,3β-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-,(25R)-;Spirostan,β-D-glucopyranoside deriv.;Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran],β-D-glucopyranoside deriv.;(3β,25R)-Spirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside;Glucopyranoside,(25R)-spirost-5-en-3β-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-,β-D-;Prosapogenin A of dioscin;Prosapogenin A;Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside;Prosapogenin A,from Dioscoreatokoro;Prosapogenin D′1;Ophiopogonin C';Progenin III;Lilioglycoside D;Polyphyllin V;25(R)-Diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside;Paris V;17-Deoxyparis VI;Saponin Ta;Paris saponin V;55916-49-9;65607-35-4
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CAS No:
Description
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis[1].
Prosapogenin A Use and Manufacturing
The steroidal saponins contained in Chonglou are the basis of their medicinal effects. Recent studies have found that Chonglou Anti-tumor can achieve anti-tumor effects by blocking the formation of new blood vessels in the tumor. It can not only fight tumors, but also reverse tumor resistance. The mechanism of Chonglou killing tumor cells is to induce tumor cell apoptosis. Chonglou saponin V is one of the important monomers of Chonglou extract and has good anticancer effects. The saponin monomer V of Chonglou saponins showed good in vitro antitumor effects on colon cancer cells. Compared with the currently commonly used anti-tumor drug oxaliplatin, saponins V has stronger anti-tumor properties on colon cancer cells and has the potential to become an effective anti-colon cancer drug.
Computed Properties
Molecular Weight:722.9
XLogP3:3
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:5
Exact Mass:722.42412741
Monoisotopic Mass:722.42412741
Topological Polar Surface Area:177
Heavy Atom Count:51
Complexity:1310
Defined Atom Stereocenter Count:21
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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