Solasonine
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Solasonine
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CAS No:
19121-58-5
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Formula:
C45H73NO16
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Chemical Name:
Solasonine
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Synonyms:
β-D-Galactopyranoside,(3β,22α,25R)-spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-;Solasonine;Spirosolane,β-D-galactopyranoside deriv.;(3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside;Solasonin;α-Solasonine;NSC 82149;77-34-9;1369-76-2;28701-66-8
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CAS No:
Description
Solasonine is a steroidal glycoalkaloid isolated from Solanum nigrum L.. Solasonine has cytotoxicity to human gastric cancer cells[1].
Characteristics
258.71000
0.11590
1.42
284-285 °C (decomp)
1.628
D23 -88° (c = 1.01 in pyridine); D22 -74.5° (c = 0.51 in methanol)
Solasonine Use and Manufacturing
1. In animal experiments, solanine has cortisone-like anti-inflammatory and anti-shock effects, but does not inhibit antibody production, reduces vascular permeability and hyaluronidase activity; it is allergic to animals, burns, and Histamine shock has certain protective effects. 2. It can also reduce the sensitivity of experimental animals to painful stimulation and have a cooling effect, similar to aspirin. 3. Increase the survival of mice with insulin shock and promote the formation of antibodies. 4. Intraperitoneal injection of rats can increase blood sugar (aglycone has no such effect). 5. Solanine has an excitatory effect on the heart and smooth muscle, and a small amount can enhance the excitatory process of the central nervous system of animals (rats, rabbits).
Computed Properties
Molecular Weight:884.1
XLogP3:1.1
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:8
Exact Mass:883.49293524
Monoisotopic Mass:883.49293524
Topological Polar Surface Area:259
Heavy Atom Count:62
Complexity:1630
Defined Atom Stereocenter Count:26
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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