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Methisazone

Methisazone structure

CAS No:
1910-68-5
Formula:
C10H10N4OS
Chemical Name:
Methisazone
Synonyms:
Hydrazinecarbothioamide,2-(1,2-dihydro-1-methyl-2-oxo-3H-indol-3-ylidene)-;Indole-2,3-dione,1-methyl-,3-(thiosemicarbazone);Isatin,1-methyl-,3-(thiosemicarbazone);2-(1,2-Dihydro-1-methyl-2-oxo-3H-indol-3-ylidene)hydrazinecarbothioamide;NSC 69811;Compound 33T57;Marboran;Methisazone;1-Methylindole-2,3-dione 3-(thiosemicarbazone);N-Methylisatin thiosemicarbazone;1-Methylisatin β-thiosemicarbazone;1-Methylisatin 3-thiosemicarbazone;Metisazone;β-Thiosemicarbazone-N-methylisatin;N-Methylisatin 3-thiosemicarbazone;N-Methylisatin-β-thiosemicarbazone;33T57;Viruzona;Metisazon;Kemoviran;MIBT;Metisazonum;BW 33T57;Isathizone;NSC 70969;Sch 16
Categories:
Chemical Reagents > Organic Reagents

Description

Metisazone is a member of indoles.|Methisazone is a thiosemicarbazone with activity against poxviruses. Methisazone inhibits the synthesis of structural viral proteins and interrupts full assembly of mature virus.|An antiviral agent effective against pox viruses.

Methisazone Basic Attributes

Molecular Weight：

234.28

Exact Mass：

234.28

EC Number：

217-616-2

UNII：

K3QML4J07E

NSC Number：

70969|69811

DSSTox ID：

DTXSID7046413

NCI Thesaurus Code：

C77928

ATC Code：

J - Antiinfectives for systemic use

HScode：

2933790090

Characteristics

PSA：

102.81000

XLogP3：

1.35650

Density：

1.3101 (rough estimate)

Melting Point：

245 °C

Boiling Point：

410.3±28.0 °C(Predicted)

Flash Point：

202ºC

Refractive Index：

1.6390 (estimate)

Vapor Pressure：

6.07E-07mmHg at 25°C

Toxicity：

LD50 oral in mouse: 4gm/kg

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

MeSH Entry Terms：

Marboran

Methisazone Use and Manufacturing

Antiviral.

Computed Properties

Molecular Weight:234.28
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:234.05753213
Monoisotopic Mass:234.05753213
Topological Polar Surface Area:108
Heavy Atom Count:16
Complexity:309
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes