4-Fluoro-7-nitrobenzofurazan
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4-Fluoro-7-nitrobenzofurazan
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CAS No:
29270-56-2
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Formula:
C6H2FN3O3
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Chemical Name:
4-Fluoro-7-nitrobenzofurazan
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Synonyms:
NBD-F (=4-Fluoro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling];7-Fluoro-4-nitro-2,1,3-benzoxadiazole;7-Nitro-4-fluoro-2,1,3-benzoxadiazole;4-Fluoro-7-nitrobenzofurazan,98%;4-Fluoro-7-nitrobenzofurazan((D)NBD-F);4-Fluoro-4-nitro-2,1,3-benzoxadiazole;4-Fluoro-7-nitrobenzofurazan,NBD-F;4-Fluoro-7-nitro-2,1
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CAS No:
Description
NBD-F is a fluorescent derivatization reagent which is originally developed for amino acid analysis.
Characteristics
84.7
1.1
Brown Crystalline Chunks
1.7±0.1 g/cm3
52-54 °C(lit.)
308.6°C at 760 mmHg
>230 °F
1.638
It is soluble in DMSO, DMF, CH3OH, CH3CN and CHCl3.
2-8°C
0.00123mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36/38
26-36-39
Xi
P305 + P351 + P338
H315-H319
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)
4-fluoro-4-nitro-2,1,3-benzoxadiazole
4-Fluoro-7-nitrobenzofurazan Use and Manufacturing
To a solution of 4-fluoro-2, 1 , 3-benzoxadiazole (1.00 g, 7.24 mmol) in Conc.H2S04 (8 ml)10 was added nitrating mixture (H2S04: HN03, 3:1, 2.40 ml) dropwise at -10°C. The reactionmixture was stirred at the same temperature for 1 h. Progress of the reaction wasmonitored by TLC and LCMS. After completion, the reaction mixture was quenched withH20 (250 ml) and extracted with EtOAc (2 x 250 ml). The organic layer was separated, dried over anhydrous Na2S04 and concentrated under vacuum. The crude obtained was15 purified by flash column chromatography (0 to 10percent EtOAc in hexanes) to afford 4-fluoro-7-nitro-2, 1 , 3-benzoxadiazole X-13a (0.39 g) as a yellow solid.Yield: 30percent1H NMR (400 MHz, DMSO-d5) o 7.70 (d, J=8.40 Hz, 1 H) 8.77- 8.80 (m, 1 H).
A fluorescence reagent
Computed Properties
Molecular Weight:183.10
XLogP3:1.1
Hydrogen Bond Acceptor Count:6
Exact Mass:183.00801910
Monoisotopic Mass:183.00801910
Topological Polar Surface Area:84.7
Heavy Atom Count:13
Complexity:222
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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