(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline
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(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline
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CAS No:
148461-14-7
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Formula:
C24H24NOP
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Chemical Name:
(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline
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Synonyms:
Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(1-methylethyl)-,(4S)-;Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(1-methylethyl)-,(S)-;(4S)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-(1-methylethyl)oxazole;(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline;(S)-(+)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-1,3-oxazoline;(S)-IPr-PHOX;(S)-(-)-2-[2-(Diphenylphosphino)phenyl]-4-(1-methylethyl)-4,5-dihydrooxazole
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CAS No:
(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline Basic Attributes
373.43
373.43
DTXSID60403391
29349990
(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline Use and Manufacturing
10mL in a reaction tube, was added phosphine ligand R-L7 (1.9mg, 0.005mmol) and bis (1, 5Cyclooctadiene) rhodium tetrafluoroborate [Rh (COD) 2] BF4 (2.1mg, 0.005mmol), through the vacuum line system, with3 times purged with nitrogen, was added freshly distilled degassed toluene (2mL), the solution was stirred for 1 hour at room temperature under reduced pressure.Removing the solvent to give a brown solid, after vacuum was 2 hours, the solvent was added 2mL of methanol, the solution was added meansZ has the formula citral (76.1mg, 0.5mmol, E / Z = 1/99, chiral rhodium complex [Rh (R-L7) (COD)] BF4 citral with molar ratio of 1/100) and iodine sodium (7.5mg, 0.05mmol) in a vial, into an autoclave, After 6 times substituted with hydrogen, so that initial hydrogen pressure of 40bar, 60 reaction was stirred for 16 hours. cool down, CAUTION gas evolution, the autoclave was opened, the vials removed, solvent drained, the conversion rate is detected NMR, gas chromatographySpectrum (column beta-DEXTM225) detection enantiomer excess value, column chromatography, to give the product. The yield was 72%R- enantiomeric excess is 78%.
Computed Properties
Molecular Weight:373.4
XLogP3:5.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:373.159551387
Monoisotopic Mass:373.159551387
Topological Polar Surface Area:21.6
Heavy Atom Count:27
Complexity:475
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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(4S)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline
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