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Ancitabine hydrochloride

Ancitabine hydrochloride structure

CAS No:
10212-25-6
Formula:
C9H11N3O4.ClH
Chemical Name:
Ancitabine hydrochloride
Synonyms:
6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,hydrochloride (1:1),(2R,3R,3aS,9aR)-;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,monohydrochloride,stereoisomer;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,monohydrochloride,[2R-(2α,3β,3aβ,9aβ)]-;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,hydrochloride;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,monohydrochloride,(2R,3R,3aS,9aR)-;2,2′-O-Cyclocytidine hydrochloride;O2,O2′-Anhydro-1-β-arabinofuranosylcytosine hydrochloride;O2,O2′-Anhydro-1-β-D-arabinofuranosylcytosine monohydrochloride;Cyclo-CMP hydrochloride;Cyclocytidine hydrochloride;2,2′-Anhydroarabinosylcytosine hydrochloride;2,2′-Anhydrocytidine hydrochloride;2,2′-Cyclocytidine hydrochloride;2,2′-Anhydro-1-β-D-arabinofuranosylcytosine monohydrochloride;NSC 145668;2,2′-Anhydroaracytidine hydrochloride;2,2′-Anhydro-1-β-D-arabinofuranosylcytosine hydrochloride;Ancitabine hydrochloride;OCTD hydrochloride;130825-73-9;135896-99-0;40390-35-0;42782-87-6;42965-86-6;42968-70-7
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

white fine crystalline powderChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of ancitabine and hydrogen chloride.

Ancitabine hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of ancitabine and hydrogen chloride. It has a role as an antimetabolite and an antineoplastic agent. It contains an ancitabine(1+).|Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.|Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.

Ancitabine hydrochloride Basic Attributes

Molecular Weight：

261.66

Exact Mass：

261.051636

EC Number：

233-515-6

UNII：

3T6920M469

DSSTox ID：

DTXSID6020357

NCI Thesaurus Code：

C403

HScode：

29213000

Characteristics

PSA：

100.59000

XLogP3：

-0.72410

Appearance：

White Powder

Density：

2.01 g/cm3

Melting Point：

248-250 °C

Boiling Point：

442ºC at 760 mmHg

Flash Point：

221.1ºC

Refractive Index：

-21 ° (C=2, H2O)

Water Solubility：

H2O 200 ( mg/mL)|EtOAc < 0.1 ( mg/mL)|CHC13 < 0.1 ( mg/mL)

Storage Conditions：

−20°C

Specific rotation：

-21.8 º (c=2,water)

Collision Cross Section：

141.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

LV2615000

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Drug Information

MeSH：

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)

MeSH Entry Terms：

Ancitabine

Ancitabine hydrochloride Use and Manufacturing

antineoplastic

Computed Properties

Molecular Weight:261.66
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:261.0516336
Monoisotopic Mass:261.0516336
Topological Polar Surface Area:98.4
Heavy Atom Count:17
Complexity:394
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Ethanol

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ancitabine Hydrochloride
Manufacturer	Bei Jing Scrianen Pharmaceutical Co., Ltd.

Registered Holders

Bei Jing Scrianen Pharmaceutical Co., Ltd.

China
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