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Epinastine hydrochloride

Epinastine hydrochloride structure

CAS No:
108929-04-0
Formula:
C16H15N3.ClH
Chemical Name:
Epinastine hydrochloride
Synonyms:
1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine,9,13b-dihydro-,hydrochloride (1:1);1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine,9,13b-dihydro-,monohydrochloride;WAL 801CL;Epinastine hydrochloride;Alesion;Elestat;80012-44-8
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

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Description

White Crystalline Solid

Epinastine hydrochloride Basic Attributes

Molecular Weight：

285.77

Exact Mass：

285.103271

EC Number：

1312995-182-4

DSSTox ID：

DTXSID1046502

HScode：

2933992600

Characteristics

PSA：

41.6

XLogP3：

3.46970

Appearance：

white

Density：

1.32g/cm3

Melting Point：

273-275 °C

Boiling Point：

428ºC at 760 mmHg

Flash Point：

212.7ºC

Water Solubility：

H2O: soluble38mg/mL

Storage Conditions：

2-8°C

Vapor Pressure：

1.56E-07mmHg at 25°C

Toxicity：

LD50 in male, female rats (mg/kg): 314, 192 orally; 17, 22 i.v. (Nishikawa)

Safety Information

Transport codes：

UN28116.1/PG3

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

HO4360000

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (97.56%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

MeSH Entry Terms：

3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine

Epinastine hydrochloride Use and Manufacturing

Uses

A tetracyclic, non-sedating histamine H1 receptor antagonist. Antihistaminic.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:285.77
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Exact Mass:285.1032752
Monoisotopic Mass:285.1032752
Topological Polar Surface Area:41.6
Heavy Atom Count:20
Complexity:378
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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