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Metaproterenol sulfate

Metaproterenol sulfate structure

CAS No:
5874-97-5
Formula:
C11H17NO3.¹/2H2O4S
Chemical Name:
Metaproterenol sulfate
Synonyms:
1,3-Benzenediol,5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-,sulfate (2:1);Benzyl alcohol,3,5-dihydroxy-α-[(isopropylamino)methyl]-,sulfate (2:1) (salt);1,3-Benzenediol,5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-,sulfate (2:1) (salt);Alotec;3,5-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol sulfate (2:1) (salt);Metaproterenol sulfate (2:1) (salt);Orciprenaline sulfate (2:1) (salt);Metaproterenol sulfate;Orciprenaline sulfate;Alupent;Th 152;1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane sulfate;Astmopent;Metaprel;(±)-Orciprenaline sulfate;dl-Metaproterenol sulfate;dl-Orciprenaline sulfate;Novasmasol;Metaproterenol hemisulfate;31023-56-0;37786-72-4;35412-74-9
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2].

A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

Metaproterenol sulfate Basic Attributes

Molecular Weight：

520.59

Exact Mass：

520.20900

EC Number：

227-539-6

DSSTox ID：

DTXSID4045391

HScode：

2922504500

Characteristics

PSA：

228

XLogP3：

3.46820

Density：

1.199g/cm3

Melting Point：

202-203 °C

Boiling Point：

417.5ºC at 760mmHg

Flash Point：

179.7ºC

Water Solubility：

Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

Toxicity：

LD50 in rats (mg/kg): 42 orally (Goldenthal)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

DO2275000

Marks：

Precautionary statement(s)：

P261

Hazard Statements：

H332

GHS Classification：

|Warning|H332 (93.33%): Harmful if inhaled [Warning Acute toxicity, inhalation]|P261, P271, P304+P312, P304+P340, and P312|Aggregated GHS information provided by 45 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)

MeSH Entry Terms：

Alotec

Metaproterenol sulfate Use and Manufacturing

Uses

Bronchodilatator;Beta-adrenergic agonist

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:520.6
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:8
Exact Mass:520.20906652
Monoisotopic Mass:520.20906652
Topological Polar Surface Area:228
Heavy Atom Count:35
Complexity:258
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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