(3-bromopyridin-2-yl)methanol
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(3-bromopyridin-2-yl)methanol
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CAS No:
52378-64-0
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Formula:
C6H6BrNO
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Chemical Name:
(3-bromopyridin-2-yl)methanol
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Synonyms:
(3-bromopyridin-2-yl)methanol;3-Bromo-2-hydroxymethylpyridine;2-PyridineMethanol, 3-broMo-;3-BroMo-2-pyridineMethanol;(3-Bromopyridin-2-yl)methanol, 3-Bromo-alpha-hydroxy-2-picoline
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CAS No:
(3-bromopyridin-2-yl)methanol Use and Manufacturing
(3-Bromopyridin-2-yl)methanol (B5.2) (0363) To a mixture of B5.1 (1 g, 5.4 mmol) in MeOH (20 mL) and THF (10 mL) was cooled to 0° C., NaBHTo a mixture of B5.1 (1 g, 5.4 mmol) in MeQH (20 mL) and THF (10 mL) was cooled to 0°C, NaBH4 (0.82 g, 21.6 mmol) wasadded in portions. The mixture was stirred for 4 h at it The mixture was concentrated, diluted with water (40 mL), extracted with DCM (40 mL x 3), the organic layer was washed with brine, dried over Na2SQ4, filtered and concentrated to give the title compound (1 g, 99percent) as a white solid. LC-MS: [M+H] = 190.0.A mixture of B6.1 (480 mg, 2.58 mmol ) in MeOH(10 mL) and THF(5 mL) was cooled to 0 N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-(2-(2-(hydroxymethyl)pyridin-3-yl)benzofuran-5- yl)acetamidea) (3-bromopyridin-2-yl)methanolTo a solution of methyl 3-bromopicolinate (1 g, 4.6 mmol) in MeOH (50 mL) at 0 °C was added NaBHTo a solution of Example 46a (2 g, 9.2 mmol) in methanol (100 mL) was added NaBHIntermediate 5 (3-Bromo-pyridin-2-yl)-methanol 3-Bromo-pyridine-2-carboxylic acid methyl ester (12.8 g, 59 2 mmol) is dissolved in methanol (150 mL) and cooled to 0° C. To the mixture is added NaBH
Computed Properties
Molecular Weight:188.02
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:186.96328
Monoisotopic Mass:186.96328
Topological Polar Surface Area:33.1
Heavy Atom Count:9
Complexity:89.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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