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GSK 690693

GSK 690693 structure

CAS No:
937174-76-0
Formula:
C21H27N7O3
Chemical Name:
GSK 690693
Synonyms:
3-Butyn-2-ol,4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-;4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol;GSK 690693;1000873-82-4
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2/13/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.

GSK 690693 Basic Attributes

Molecular Weight：

425.48

Exact Mass：

425.48

HScode：

2934999090

Characteristics

PSA：

137

XLogP3：

0.3

Appearance：

white to beige

Density：

1.4±0.1 g/cm3

Boiling Point：

683.8ºC at 760 mmHg

Flash Point：

367.3±34.3 °C

Refractive Index：

1.683

Water Solubility：

DMSO: soluble5mg/mL (clear solution)

Storage Conditions：

2-8°C

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GSK 690693 Use and Manufacturing

GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively

Recommended Suppliers of GSK 690693

Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

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GSK690693 99% see COA Kanbei kanbei

CAS No.: 937174-76-0

Grade: Industrial Grade

Content: 99%

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