Pyroxamide
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Pyroxamide
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CAS No:
382180-17-8
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Formula:
C13H19N3O3
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Chemical Name:
Pyroxamide
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Synonyms:
2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide;PyroxaMide (NSC 696085);N1-Hydroxy-N8-3-pyridinyl-octanediamide;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-;N-Hydroxy-N'-3-pyridinyloctanediamide;Pyroxamide
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CAS No:
Description
Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia.
N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.|Pyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others.|Pyroxamide is a synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. (NCI04)
Characteristics
91.3
0.04
white to beige
1.2±0.1 g/cm3
1.570
DMSO: soluble10mg/mL (clear solution)
-20°C
Pyroxamide Use and Manufacturing
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.
Computed Properties
Molecular Weight:265.31
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:265.14264148
Monoisotopic Mass:265.14264148
Topological Polar Surface Area:91.3
Heavy Atom Count:19
Complexity:284
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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