 Home > Encyclopedia > 6-Hydroxypicolinic acid

6-Hydroxypicolinic acid

6-Hydroxypicolinic acid structure

CAS No:
19621-92-2
Formula:
C6H5NO3
Chemical Name:
6-Hydroxypicolinic acid
Synonyms:
2-Pyridinecarboxylic acid,1,6-dihydro-6-oxo-;Picolinic acid,1,6-dihydro-6-oxo-;Picolinic acid,6-hydroxy-;1,6-Dihydro-6-oxo-2-pyridinecarboxylic acid;6-Hydroxypicolinic acid;6-Hydroxypyridine-2-carboxylic acid;2-Oxo-1,2-dihydropyridine-6-carboxylic acid;2-Hydroxypyridine-6-carboxylic acid;NSC 51589;6-Oxo-1,6-dihydropyridine-2-carboxylic acid;6-Hydroxy-2-picolinic acid;6-Oxopyridine-2-carboxylic acid;6-Oxo-1H-pyridine-2-carboxylicacid;19837-41-3
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

Description

Light yellow Cryst

6-Hydroxypicolinic acid is an aromatic carboxylic acid and a member of pyridines.

6-Hydroxypicolinic acid Basic Attributes

Molecular Weight：

139.11

Exact Mass：

139.11

EC Number：

417-690-8

NSC Number：

51589

DSSTox ID：

DTXSID10287567

HScode：

29333990

Characteristics

PSA：

66.4

XLogP3：

-0.1

Appearance：

Yellow to brown Powder

Density：

1.451±0.06 g/cm3(Predicted)

Melting Point：

282 °C (decomp)

Boiling Point：

436.0±45.0 °C(Predicted)

Flash Point：

251.9±24.6 °C

Refractive Index：

1.626

Vapor Pressure：

8.03E-09mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P332+P313, P333+P313, P337+P313, P362, P363, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

6-hydroxypicolinic acid

6-Hydroxypicolinic acid Use and Manufacturing

To a solution of 2-bromo-6-hydroxypyridine (0.76 g, 4.4 mmol, 1.0 equiv.) in dry THF (20 mL) at 0 C was added a 2 M solution of -PrMgCl in THF (2.2 mL, 4.4 mmol, 1.0 equiv.) during 5 min. The clear solution was stirred at that temperature for anadditional 5 min, and a 2.5 M solution of n-BuLi in hexanes (3.5 mL, 8.8 mmol, 2.0 equiv.) wasadded dropwise during 5min, while maintaining the temperature below 20 C. The resultingmixture was stirred at that temperature for 0.5 h, dry CO2 (0.20 g, 1.0 equiv.) was added to20 C. The resulting mixture was warmed to 20 C in 0.5 h and quenched with water (6 mL).After stirring the mixture below 20 C for 10 min, the phases were separated and the water phasewas extracted one additional time with ethyl acetate. The resulting suspension was allowed to reachroom temperature and fitered through a mbox0.5 1 cm pad of silica gel eluted with 10 mL of ethylacetate. The ®ltrate was concentrated and the residue was puri®ed by ash chromatography on silicagel (eluent: petroleum ether/ethyl acetate = 10:1) to afford product 3m as off-white solid, 0.56 g (yield: 93percent) , m.p.: 275–277 C. 1H-NMR (600 MHz, DMSO) 7.56 (dd, J = 8.9, 7.0 Hz, 1H), 6.97 (d, J = 6.8 Hz, 1H), 6.65 (d, J = 9.0 Hz, 1H). 13C-NMR (151 MHz, DMSO) 163.28, 162.67, 140.51, 137.97, 123.88, 110.42.

Computed Properties

Molecular Weight:139.11
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:139.026943022
Monoisotopic Mass:139.026943022
Topological Polar Surface Area:66.4
Heavy Atom Count:10
Complexity:239
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 6-Hydroxypicolinic acid

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

6-Hydroxypicolinic acid

CAS No.: 19621-92-2

Content: 99.00%

Inquiry
Shanxi Yongjin Group Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of 3,4-Dihydroxybenzaldehyde,3,4- Dibenzyloxybenzaldehyde,1,4- Dimethoxybenzene,4-Caffeic acid,3,5Dibenzyloxyacetophen one,4-Hydroxybenzaldehyde,Piperazine,1-(2- methoxyphenyl),2,4-Dihydroxybenzaldehyde,2,4-Dihydroxybenzoic acid

19621-92-2,6-Hydroxy-2-pyridinecarboxylic acid,99,6-Hydroxypicolinic acid, 6-Hydroxypyridine-2-carboxylic acid, 6-HPA, 6-hydroxypicolinic acid, 6-CARB

CAS No.: 19621-92-2

Grade: Cosmetics Grade

Content: 99%

Inquiry