 Home > Encyclopedia > 5-Bromo-2-nitropyridine

5-Bromo-2-nitropyridine

5-Bromo-2-nitropyridine structure

CAS No:
39856-50-3
Formula:
C5H3BrN2O2
Chemical Name:
5-Bromo-2-nitropyridine
Synonyms:
Pyridine,5-bromo-2-nitro-;5-Bromo-2-nitropyridine;3-Bromo-6-nitropyridine;2-Nitro-5-bromopyridine
Categories:
Pharmaceutical Intermediates > Antineoplastics

Request for Quotation

Description

Colorless solid

5-Bromo-2-nitropyridine Basic Attributes

Molecular Weight：

202.99

Exact Mass：

202.99

BRN：

120878

EC Number：

1592732-453-0

DSSTox ID：

DTXSID20355827

HScode：

2933399090

Characteristics

PSA：

58.7

XLogP3：

1.7

Density：

1.8±0.1 g/cm3

Melting Point：

149.5-150 °C

Boiling Point：

331.2°C at 760 mmHg

Flash Point：

130.6±21.8 °C

Refractive Index：

1.614

Safety Information

Packing level：

III

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36/37

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 54 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-bromo-2-nitropyridine

5-Bromo-2-nitropyridine Use and Manufacturing

500 L of glacial acetic acid and 150 L of acetic acid recovered in were charged into a 1000 L autoclave, and the circulating water was stirred and stirred. After homogeneous mixing, 120 kg of 2-amino-5-bromopyridine was slowly added and the temperature was controlled at 20C. , Stirring 30min, slowly dropping 300kg peracetic acid, when dropping to about 50kg, the temperature began to slowly rise, stop dropping, when the temperature does not rise began to decline, and then dropping the remaining amount, until the peracetic acid plus Finished, the whole process temperature control at 30 . After completion of the dropwise addition, the temperature was controlled at 40 ° C and the reaction was carried out at constant temperature for 20 hours. When the reaction is complete, vacuum distillation, steaming about 600L acetic acid, to stop the distillation. The remaining liquid cooling to 25 , and then add 500L of water, with 40percent sodium hydroxide solution to adjust the pH value of the material to 8, cooled to -20 , filtration, drying, 125kg solid, crude The yield was 89.3percent. The recrystallized product was 120.5kg and the yield was 86.1percent.Add 1000ml of 30percent hydrogen peroxide solution to a 1000ml three-neck reaction flask, cool down to 15 °C with a low temperature reaction bath, and drop 320ml of 98percent concentrated sulfuric acid into the hydrogen peroxide water in the reaction bottle with a constant pressure dropping funnel. The temperature of the solution in the bottle is controlled at 5 In the range of -15 ° C, the solution B was added dropwise. At the same time, 160ml of 98percent concentrated sulfuric acid was added to another 1000ml three-neck reaction flask, and 60.00g of 2-amino-5-bromopyridine was added in batches by a low temperature reaction bath, and the temperature was controlled within the range of 5-15 °C.The solution A was obtained after the addition.The A and B solutions are all prepared, and the solution B is added dropwise to the solution A by a constant pressure dropping funnel, and the temperature of the reaction bottle is controlled by the low temperature reaction bath in the range of 0-10 ° C, and the optimum temperature is 5 ° C. The temperature change value was not more than 3 ° C. After the dropwise addition was completed, the reaction liquid was slowly heated to 50 ° C, the reaction was continued for 3 hours, and the sample was taken for TLC analysis to disappear.Add 5000 ml of water to a 5000 ml three-neck reaction flask, and cool to within 15 ° C. The above reaction solution is added to water with a constant pressure dropping funnel while stirring, and the temperature is controlled within a range of -15 ° C. After the dropwise addition is completed, Continue stirring for 18-20 minutes. At 5-15 ° C, 720 g of 30percent liquid alkali was added, stirring was continued for 0.5 hours, then filtered under reduced pressure, washed with 100 ml of water, and the filter cake was neutralized with a dilute alkali to pH = 7 and filtered again. The resulting solid was recrystallized from methanol and filtered hot.Dry to give a pale yellow solid of 51.13 g of product.Yield 73.4percent, The purity of the product liquid chromatography is greater than 99percent.Reference 5-Bromo-2-nitro-pyridine. A solution of 2-amino-5-bromo-pyridine (5 g, 28.9 mmol) in cone, sulfuric acid (10 mL) was added dropwise to a cold (0

Computed Properties

Molecular Weight:202.99
XLogP3:1.7
Hydrogen Bond Acceptor Count:3
Exact Mass:201.93779
Monoisotopic Mass:201.93779
Topological Polar Surface Area:58.7
Heavy Atom Count:10
Complexity:136
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5-Bromo-2-nitropyridine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

5-Bromo-2-nitropyridine 99% solid 39856-50-3 Dideu

CAS No.: 39856-50-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

5-Bromo-2-nitropyridine

CAS No.: 39856-50-3

Grade: industrial Grade

Content: 98%

Inquiry
Shandong Boyuan Pharmaceutical Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Terbinafine hydrochloride,Carboplatin,Pramipexole dihydrochloride Monohydrate,Cisatracurium Besylate,Rivaroxaban,Lenvatinib,Febuxostat,Pemetrexed,Capecitabine,Oxaliplatin,Cisplatin,Ezetimibe,Mitiglinide Calcium,Lapatinib,Dasatinib,Osimertinib,Olaparib,Palbociclib,Lenalidomide,Bortezomib,Enzalutamide,Pemetrexed disodium heptahydrate,Ropivacaine HCL,Atracurium Besylate,Racecadotril,Apremilast,Vonoprazan Fumarate,Crisaborole,Rimegepant

AKOSBBS-00001330;2-NITRO-5-BROMOPYRIDINE;5-BROMO-2-NITROPYRIDINE;3-BROMO-6-NITROPYRIDINE;2-NITRO-5-BROMOPYRIDINE(5-BROMChemicalbookO-2-NITROPYRIDINE);

CAS No.: 39856-50-3

Grade: Industrial Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high quality 5-Bromo-2-nitropyridine 99% transparent liquid KANBEI

CAS No.: 39856-50-3

Grade: Industrial Grade

Content: 99%

Inquiry
NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

5-Bromo-2-nitropyridine

CAS No.: 39856-50-3

Grade: Industrial Grade

Content: 99%

Inquiry