(-)-α-Bisabolol

222.37

222.37

245-423-3

24WE03BX2T

DTXSID4042094|DTXSID5045964

2906195000

20.2

5.07

clear to yellowish liquid

0.9211 g/cm³ @ Temp: 20 °C

153 °C @ Press: 12 Torr

135 °C

1.494

1.688 mg/L @ 25 °C (est)|Practically insoluble or insoluble in water|Slightly soluble (in ethanol)

-20°C

4E-05mmHg at 25°C

LD50 in male, female mice, rats (ml/kg): 15.2, 15.0, 14.9, 15.6 orally (Habersang)

D -55.7°; D20 -51.02° (Günther)

UN 3082 9 / PGIII

3

MJ9685000

P261, P272, P273, P280, P302+P352, P321, P333+P313, P363, P391, P501

H317

|Warning|H317 (34.72%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P273, P280, P302+P352, P321, P333+P313, P363, P391, and P501|Aggregated GHS information provided by 228 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H317 (83.52%): May cause an allergic skin reaction [Warning Sensitization, Skin]|Aggregated GHS information provided by 278 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain molecules

Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus, and ameliorate skin texture and elasticity.

The purpose of the present investigations was to study the cutaneous absorption of sesquiterpenic alcohol, the major active principle of chamomile. For these investigations 14C-labelled levomenol ((-)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (-)-alpha-bisabolol) was prepared by biochemical incorporation of [14C]-acetate into the molecule. 5 h after topical application of the radiolabelled substance onto nude mice half of the radioactivity was found in the skin. The other part was measured in tissue and organes. 90% of this radioactivity was analysed as intact levomenol.|To demonstrate the distribution of the substance in the skin a part of this tissue was cutted into horizontal slices by a cryotome. From the slices autoradiograms were produced. The densitometric measuration showed that there was a fast penetration of levomenol into the skin. 5 h after the topical application the substance was displaced from outermost to innermost areas. From these results a fast cutaneous absorption and a long therapeutical effect of the antiphlogistic and spasmolytic levomenol in the skin can be expected.

(+)-4-epi-alpha-bisabolol

3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-penten-1-yl)-, (.alpha.R,1R)-rel-: ACTIVE

Food additives -> Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT; -> JECFA Functional Classes|Flavoring Agents -> JECFA Flavorings Index|Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> C15 isoprenoids (sesquiterpenes) [PR0103]|Cosmetics -> Soothing

Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT;