2-Acetylamidomethyl-4-(4-fluorobenzyl)morpholine

REFERENCE EXAMPLE 6 Preparation of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine A mixture of 2-acetylaminomethylmorpholine (7.0 g), 4-fluorobenzyl chloride (12 g), potassium carbonate (56 g), potassium iodide (1 g), and methyl ethyl ketone (100 ml) is refluxed with stirring for 17 hours. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is diluted with water and extracted with chloroform. The organic layer is separated, washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure, and the residue is recrystallized from toluene to give the title compound (9.3 g), mp 120-122 C.REFERENCE EXAMPLE 56 Preparation of 2-aminomethyl-4-(4-fluorobenzyl)morpholine A solution of

Molecular Weight:266.31
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:266.14305602
Monoisotopic Mass:266.14305602
Topological Polar Surface Area:41.6
Heavy Atom Count:19
Complexity:293
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes