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[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone

[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone structure

CAS No:
164178-33-0
Formula:
C23H25IN2O3
Chemical Name:
[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone
Synonyms:
Methanone,[6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-;[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone;AM 630;Iodopravadoline;[6-Iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone

Description

6-Iodopravadoline (AM630) is a selective CB2 antagonist with Ki of 31.2 nM, and displays 165-fold selectivity over CB1 receptors.

[6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-3-indolyl]-(4-methoxyphenyl)methanone is a N-acylindole.

[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone Basic Attributes

Molecular Weight：

504.36

Exact Mass：

504.36

UNII：

U1LNJ6NBKA

DSSTox ID：

DTXSID10167719

Characteristics

PSA：

43.7

XLogP3：

4.65

Appearance：

white to beige

Density：

1.49±0.1 g/cm3(Predicted)

Boiling Point：

605.9±55.0 °C(Predicted)

Flash Point：

320.3±31.5 °C

Refractive Index：

1.647

Water Solubility：

DMSO: >5mg/mL

Storage Conditions：

Desiccate at +4°C

Vapor Pressure：

1.25E-14mmHg at 25°C

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P273-P501

Hazard Statements：

H410

Drug Information

MeSH：

Compounds that interact with and stimulate the activity of CANNABINOID RECEPTORS. (See all compounds classified as Cannabinoid Receptor Agonists.)

MeSH Entry Terms：

1-(2-(morpholin-4-yl)ethyl)-2-methyl-3-(4-methoxybenzoyl)-6-iodoindole

[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone Use and Manufacturing

AM 630 acts as a potential CB2 receptor cannabinoid antagonist with application towards human lung cancer treatment and angiogenesis induction.

Computed Properties

Molecular Weight:504.4
XLogP3:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:504.09099
Monoisotopic Mass:504.09099
Topological Polar Surface Area:43.7
Heavy Atom Count:29
Complexity:548
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of [6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties

[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone

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