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Almokalant

Almokalant structure

CAS No:
123955-10-2
Formula:
C18H28N2O3S
Chemical Name:
Almokalant
Synonyms:
Benzonitrile,4-[3-[ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]-;4-[3-[Ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]benzonitrile;Almokalant;H 234/09
Categories:
Organic Chemistry > Amides

Description

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.

Almokalant Basic Attributes

Molecular Weight：

352.496

Exact Mass：

352.49

Characteristics

PSA：

92.8

XLogP3：

3.03438

Density：

1.17g/cm3

Boiling Point：

574.8ºC at 760mmHg

Flash Point：

301.4ºC

Refractive Index：

1.567

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

4-(3-(ethyl(3-(propylsulfinyl)propyl)amino)-2-hydroxypropoxy)benzonitrile

Computed Properties

Molecular Weight:352.5
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:352.18206393
Monoisotopic Mass:352.18206393
Topological Polar Surface Area:92.8
Heavy Atom Count:24
Complexity:402
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes