Ametantrone
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Ametantrone
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CAS No:
64862-96-0
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Formula:
C22H28N4O4
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Chemical Name:
Ametantrone
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Synonyms:
9,10-Anthracenedione,1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-;1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione;Ametantrone;NSC 196473;1,4-Bis[2-(2-hydroxyethylamino)ethylamino]anthraquinone;NSC 290813
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CAS No:
Description
Ametantrone is a topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA of tumor cells.
Characteristics
123
-0.63
1.3±0.1 g/cm3
156-158 °C
708.8±60.0 °C at 760 mmHg
382.4±32.9 °C
1.672
Flammable; decomposes toxic nitrogen oxide fumes when heated
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)
1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-anthracenedione diacetate
Computed Properties
Molecular Weight:412.5
XLogP3:1.7
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:412.21105539
Monoisotopic Mass:412.21105539
Topological Polar Surface Area:123
Heavy Atom Count:30
Complexity:513
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes