Ametantrone acetate
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Ametantrone acetate
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CAS No:
70711-40-9
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Formula:
C22H28N4O4.2C2H4O2
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Chemical Name:
Ametantrone acetate
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Synonyms:
9,10-Anthracenedione,1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,acetate (1:2);9,10-Anthracenedione,1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,diacetate (salt);NSC 287513;Ametantrone acetate;CI 881;73334-06-2
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CAS No:
Description
Ametantrone Acetate is acetate salt of Ametantrone, a topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA.
Characteristics
212
Oral-mouse LD50: 495 mg/kg; peritoneal-mouse LD50: 62.83 mg/kg
Flammable; decomposes toxic nitrogen oxide fumes when heated
Safety Information
Treasury is ventilated, low temperature and dry; stored separately from food materials
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)
1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-anthracenedione diacetate
Computed Properties
Molecular Weight:532.6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:12
Exact Mass:532.25331412
Monoisotopic Mass:532.25331412
Topological Polar Surface Area:212
Heavy Atom Count:38
Complexity:539
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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