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Amicarthiazol

Amicarthiazol structure

CAS No:
21452-14-2
Formula:
C11H11N3OS
Chemical Name:
Amicarthiazol
Synonyms:
5-Thiazolecarboxamide,2-amino-4-methyl-N-phenyl-;5-Thiazolecarboxanilide,2-amino-4-methyl-;2-Amino-4-methyl-N-phenyl-5-thiazolecarboxamide;Uniroyal F 849;2-Amino-4-methylthiazole-5-carboxanilide;F 849;Sidvax;ALF;Seedvax;Amicarthiazol;2-Amino-4-methylthiazole-5-carboxylic acid anilide;2-Amino-4-methyl-N-phenyl-1,3-thiazole-5-carboxamide;2-Amino-4-methyl-thiazole-5-carboxylic acid phenylamide;118064-82-7;1135441-88-1
Categories:
Organic Chemistry > Amides

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Amicarthiazol Basic Attributes

Molecular Weight：

233.289

Exact Mass：

233.29

HScode：

2934100090

Characteristics

PSA：

96.2

XLogP3：

2.60010

Density：

1.375g/cm3

Melting Point：

222-223 °C

Boiling Point：

354.5ºC at 760mmHg

Flash Point：

168.2ºC

Refractive Index：

1.711

Water Solubility：

999mg/L(temperature not stated)

Storage Conditions：

-20°C

Vapor Pressure：

3.34E-05mmHg at 25°C

Toxicity：

Oral-rat LD50: 1410 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

22-36/37/38

safety instructions：

RTECS Number：

XJ2700000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH Entry Terms：

2-amino-4-methylcarboxanilithiazol

Amicarthiazol Use and Manufacturing

Methods of Manufacturing

The process is carried out according to the following steps: (1) Synthesis of α-chloroacetoacetanilide (chlorination) Add acetoacetanilide and toluene into the reactor, add sulfuryl chloride dropwise at about 20°C under stirring, and control the reaction temperature at At 25-30°C, the dripping is completed in half an hour, and the reaction is continued for 2.5 hours, which is a toluene suspension of α-chloroacetoacetanilide. (2) Fenzhongling synthesis (condensation): add thiourea and water to the toluene suspension obtained in the first step, heat to reflux, and react for half an hour. After the reaction is completed, stand for layering, the upper layer is the toluene layer, which can be continuously applied, and the lower layer is the aqueous solution of Fenzhongling hydrochloride. Separate the water layer and dilute with water, add ammonia water under stirring to neutralize the precipitate formed by filtration to pH 8 and wash it with water until it is nearly neutral, and dry it to obtain a white powdery product with a content of about 96%. The yield of acetoacetanilide is about 8%. Raw material consumption quota: acetoacetanilide (>98) 880kg/t, sulfuryl chloride (100%) 700kg/t, thiourea (>95%) 410kg/t, ammonia (25%) 520kg/t.

Uses

Systemic fungicides, which also have the role of plant hormones. Soaking seeds with 0.25% to control kenaf anthracnose, the control effect is as high as 100% for two consecutive years, and the seed dressing effect is also more than 98%; the effect of preventing cereal smut and cotton corner spot is equivalent to Sailisan and Lianglisheng. It also has control effects on rice bacterial blight and flower rust. The main use of this product is seed dressing or seed soaking, the general usage is 0.3-0.5% of the seed weight.

Computed Properties

Molecular Weight:233.29
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:233.06228316
Monoisotopic Mass:233.06228316
Topological Polar Surface Area:96.2
Heavy Atom Count:16
Complexity:256
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes