Ethylmorpholine

115.17

115.17

202-885-0

ECM0G991FQ

0480

6110

1993

DTXSID5025312

COLORLESS LIQUID|Colorless liquid.

29349990

12.5

0

N-ethyl morpholine appears as a colorless liquid with a strong ammonia-like odor. Severely irritates skin, eyes, and mucous membranes. Moderately soluble in water and less dense than water. Flash point 83°F .

0.8996 g/cm³ @ Temp: 20 °C

-62.78 °C

138-139 °C @ Press: 763 Torr

82 °F

n 20/D 1.441(lit.)

Moderately soluble in water .

Store in a detached storehouse without any ignition source.

8.1 hPa (20 °C)

4

LD50 orally in Rabbit: 1640 mg/kg LD50 dermal Rabbit 900 mg/kg

Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.

1.9%(V)

AMMONIACAL ODOR

pKa = 7.67 (conjugate acid)

WT/GAL: 7.6 LB @ 20 °C|MODERATELY VOLATILE

Highly flammable. Moderately soluble in water .

Amines, Phosphines, and Pyridines

Highly Flammable

N-ETHYL MORPHOLINE can react vigorously with oxidizing materials. It dissolves LiAlH4. (NTP, 1992)

185 °C

Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.

36.94 kJ/mole @ 101.3 kPa

II

8

UN2920 Corrosive liquids, flammable, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid. UN1993 Flammable liquids, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, Technical Name RequiredUN 2920 8/PG 2

1

R10; R21/22; R34

26-36/37/39-45-16

QE4025000

C

Fireproof. Separated from strong oxidants.

Stable. Flammable. Incompatible with strong oxidizing agents. Slightly air sensitive.

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P311, P312, P314, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, P501

H226

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN A SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE.

...CAN REACT VIGOROUSLY WITH OXIDIZING MATERIALS.|Strong acids, strong oxidizers.

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as ammonia, nitrogen oxides, and carbon monoxide, may be formed when involved in fire. Behavior in Fire: Can react vigorously with heat or flame. (USCG, 1999)|Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 32 °C explosive vapour/air mixtures may be formed.|Flammable - 3rd degree

|Danger|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 461 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P311, P312, P314, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Warning|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P281, P301+P312, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P330, P332+P313, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided (when concentration is >15%) in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Recommendations for respirator selection. Max concn for use: 50 ppm. Respirator Class(es): Any chemical cartridge respirator with organic vapor cartridge(s). May require eye protection. Any supplied-air respirator. May require eye protection.|Recommendations for respirator selection. Max concn for use: 100 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. May require eye protection. Any powered, air-purifying respirator with organic vapor cartridge(s). May require eye protection. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s). Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.|Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator with a full facepiece and operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode.|Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.|For more Personal Protective Equipment (PPE) (Complete) data for N-ETHYLMORPHOLINE (8 total), please visit the HSDB record page.|(See protection codes)

...A DANGEROUS FIRE HAZARD...

1.0% & 9.8% BY VOLUME IN AIR.|/IF SPILLED OR LEAKED/...SHOULD NOT BE ALLOWED TO ENTER A CONFINED SPACE, SUCH AS A SEWER, BECAUSE OF THE POSSIBILITY OF AN EXPLOSION.|Explosive limits , vol% in air: 1-9.8

ALCOHOL FOAM, FOAM, CARBON DIOXIDE, DRY CHEMICAL.|WATER MAY BE INEFFECTIVE.

1) REMOVE ALL IGNITION SOURCES. 2) VENTILATE AREA OF SPILL OR LEAK. 3) FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS.|Cover with the 9:1 mixture of sand and soda ash. After mixing, transfer into a paper carton, stuffed with ruffled paper. Burn in an open furnace with the utmost care or in the furnace with afterburner and scrubber.

...GOOD VENTILATION IS VERY IMPORTANT. /MORPHOLINE/|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet should be immediately removed due to its flammability hazard.|Take off the clothing followed by drying and washing or disposing. Dispose shoes by incineration.

... Ten humans exposed at 100 ppm N-ethylmorpholine for 2.5 min experienced irritation to the eyes, nose, and throat and olfactory fatigue. Irritation was slight with the same duration of exposure at 50 ppm and absent at 25 ppm.

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 20 ppm (94 mg/cu m). Skin Designation.|Vacated 1989 OSHA PEL TWA 5 ppm (23 mg/cu m), skin designation, is still enforced in some states.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (23 mg/cu m), skin.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Separated from strong oxidants.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the eyes. This may result in distortion of vision.

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Above 32 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or eye protection in combination with breathing protection.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

The oral, single-dose LD50 for rats was 1.78 g/kg (1.49-2.12 g/kg) ...

N-Ethylmorpholine's use as an intermediate for dyestuffs, pharmaceuticals, rubber accelerators, and emulsifying agents(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Using a structure estimation method based on molecular connectivity indexes(1), the Koc for N-ethylmorpholine can be estimated to be about 12(SRC). According to a suggested classification scheme(2), this estimated Koc value suggests that N-ethylmorpholine has very high soil mobility(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC). Volatilization of N-ethylmorpholine is expected from dry soils(SRC) based on an experimental vapor pressure of 5 mm Hg(3,SRC), but not important from moist soils(SRC) based on an estimated Henry's Law constant of 2.74X10-8 atm-cu m/mole(4,SRC).|AQUATIC FATE: Based on a suggested classification scheme(2), N-Ethylmorpholine will be essentially non-volatile from water(SRC) based upon an estimated Henry's Law constant of 2.74X10-8 atm-cu m/mol(1,SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in natural waters(SRC).|ATMOSPHERIC FATE: Based on an experimental vapor pressure of approximately 5 mm Hg at 25 °C(1), and a suggested classification scheme(2), N-ethylmorpholine will exist primarily in the vapor phase in the atmosphere(SRC). It will degrade in the ambient atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 2.5 hours(3,SRC). Removal of atmospheric N-ethylmorpholine may occur through wet deposition(SRC).

The rate constant for the vapor-phase reaction of N-ethylmorpholine with photochemically produced hydroxyl radicals has been estimated to be approximately 1.49X10-10 cu cm/molecule-sec at 25 °C which corresponds to an atmospheric half-life of about 2.5 hours at an atmospheric concentration of 5x10+5 hydroxyl radicals per cu cm(1,SRC).

Because it is miscible in water(2), bioconcentration in aquatic organisms is not expected to be an important fate process for N-ethylmorpholine(1,SRC).

Using a structure estimation method based on molecular connectivity indexes(1), the Koc for N-ethylmorpholine can be estimated to be about 12(SRC). According to a suggested classification scheme(2), this estimated Koc value suggests that N-ethylmorpholine has very high soil mobility(SRC).

The Henry's Law constant for N-ethylmorpholine can be estimated to be 2.47X10-8 atm-cu m/mole(SRC) using a structure estimation method(1). This value of Henry's Law constant indicates that N-ethylmorpholine will be essentially non-volatile from water(2).

...HAS PECULIARLY DISTURBING ACTION ON CORNEAL EPITHELIUM...CAUSING TRANSIENT EDEMA OF CORNEAL EPITHELIUM IN WORKERS EXPOSED TO 40 PPM OR MORE IN AIR DURING WORK DAY, CAUSING ONSET OF BLUE-GREY VISION OR COLORED HALOS AROUND LIGHTS A FEW HOURS AFTER EXPOSURE.|Occupational exposure to morpholines, such as N-ethylmorpholine, can occur through inhalation, dermal contact and ingestion(1).

...ABSORBED THROUGH UNBROKEN SKIN.

Exposure can cause irritation of eyes, nose and throat. Contact with eyes may result in foggy vision and seeing halos around lights. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

... Ten humans exposed at 100 ppm N-ethylmorpholine for 2.5 min experienced irritation to the eyes, nose, and throat and olfactory fatigue. Irritation was slight with the same duration of exposure at 50 ppm and absent at 25 ppm.|Corneal edema was observed in workers exposed at 40 ppm and more N-ethylmorpholine for several hr. The lesions appeared near the end of the work shift and cleared within 3 to 4 hr after cessation of exposure. Other investigators have also reported that corneal edema caused by amine vapors is reversible. Distortion of vision is experienced at concn below those which produce eye or respiratory irritation. Another study reported that workers exposed at concn generally in the 3 to 4 ppm N-ethylmorpholine range, and never above 11 ppm, complained of drowsiness, optical halos, and foggy vision.|... An epidemic of neurogenic urinary retention from a company, employing 141 and 75 people at 2 different plants, manufacturing polyurethane foam products ... Abnormalities in vision, upper respiratory irritation, dermatitis, and pulmonary abnormalities also occurred but appeared to be related to the presence of other chemicals including N-ethylmorpholine and toluene diisocyanate.

4-ethylmorpholine

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, nose, throat; visual disturbance: corneal edema, blue-gray vision, colored haloes

Cough. Sore throat.

Redness.

Redness. Pain. Blurred vision.

Eyes, respiratory system

GRADE: TECHNICAL.

Plastic material and resin manufacturing|Morpholine, 4-ethyl-: ACTIVE

MATRIX: AIR; PROCEDURE: ADSORPTION ON SILICA GEL, DESORPTION WITH AQUEOUS SULFURIC ACID, GC. RANGE: 57-206 MG/CU M.

Fire Hazards -> Flammable - 3rd degree