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2-(Aminoiminomethyl)benzo[b]thiophen-6-ylester-2-Thiophenecarboxylicacid

2-(Aminoiminomethyl)benzo[b]thiophen-6-ylester-2-Thiophenecarboxylicacid structure

CAS No:
217099-43-9
Formula:
C14H10N2O2S2
Chemical Name:
2-(Aminoiminomethyl)benzo[b]thiophen-6-ylester-2-Thiophenecarboxylicacid
Synonyms:
2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate;BCX 1470;BCX-1470;CHEMBL2220483;(2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate;2-(Aminoiminomethyl)benzo[b]thiophen-6-yl ester-2-Thiophenecarboxylic acid;cc-543;SCHEMBL7614663;DTXSID30431348

Description

BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

2-(Aminoiminomethyl)benzo[b]thiophen-6-ylester-2-Thiophenecarboxylicacid Basic Attributes

Molecular Weight：

302.377

Exact Mass：

302.018372

DSSTox ID：

DTXSID30431348

Characteristics

PSA：

132.65000

XLogP3：

3.71

Density：

1.5±0.1 g/cm3

Boiling Point：

509.9±58.0 °C at 760 mmHg

Flash Point：

262.2±32.3 °C

Refractive Index：

1.751

Drug Information

MeSH Entry Terms：

2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate

Computed Properties

Molecular Weight:302.4
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:302.01836991
Monoisotopic Mass:302.01836991
Topological Polar Surface Area:133
Heavy Atom Count:20
Complexity:405
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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BCX 1470

CAS No.: 217099-43-9

Content: 0.98%

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Guide of 2-(Aminoiminomethyl)benzo[b]thiophen-6-ylester-2-Thiophenecarboxylicacid

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
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