BCX 1470
217099-43-9
0.98%
2026-07-09
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName BCX 1470 Cat No CEI-1240 Product Overview C1s is an 80-kDa serine protease that mediates the proteolytic activity of the C1 complex by cleaving C2 and C4 both. BCX-1470, discovered in 1997 as a FD inhibitor (IC50=96 nM), was further found to be a very potent C1s inhibitor (IC50=1.6 nM). Clinical trial: BCX-1470 has also been tested for safety in clinical trials with healthy volunteers but the outcome of these trials have not officially been published. Whereas no further clinical trials have been reported, a recent patent might indicate a future usage of the compound in the treatment of AMD. It suggests that BCX-1470 would be a candidate therapeutic for complement activation during cardiopulmonary bypass surgery. CAS No 217099-43-9 Molecular Weight 302.38 Purity 0.98 Storage Store at -20°C Synonyms Thrombin inhibitor; BCX 1470; BCX-1470; Targets Serine protease IC50 FD 96 nM, C1 1.6 nM Molecular Formula C14H10N2O2S2 Chemical Name (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro BCX-1470 has the highest inhibitory activity of Factor D, with an IC50 of approx. 100 nM, which is two orders higher than the inhibitory activity of another commercially available general protease inhibitor, named FUT-175, when inhibting FD. In vivo BCX-1470 has been shown to be safe in animal toxicity studies and has blocked the development of reverse-passive Arthus reactioninduced oedema in rats. category Specialty Chemicals(c26) cas_num 217099-43-9 Basic Info-
Product Name:
2-(Aminoiminomethyl)benzo[b]thiophen-6-ylester-2-Thiophenecarboxylicacid
Other Name:2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate;BCX 1470;BCX-1470;CHEMBL2220483;(2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate;2-(Aminoiminomethyl)benzo[b]thiophen-6-yl ester-2-Thiophenecarboxylic acid;cc-543;SCHEMBL7614663;DTXSID30431348
CAS No.:217099-43-9
Molecular Formula:C14H10N2O2S2
InChIKeys:OTGQTQBPQCRNRG-UHFFFAOYSA-N
Molecular Weight:302.377
Exact Mass:302.018372
DSSTox ID:DTXSID30431348
Categories:
Characteristics-
PSA:
132.65000
XLogP3:3.71
Density:1.5±0.1 g/cm3
Boiling Point:509.9±58.0 °C at 760 mmHg
Flash Point:262.2±32.3 °C
Refractive Index:1.751
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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