3-Amino-2-azepanone
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3-Amino-2-azepanone
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CAS No:
17929-90-7
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Formula:
C6H12N2O
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Chemical Name:
3-Amino-2-azepanone
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Synonyms:
(R/S)-ALPHA-AMINO-OMEGA-CAPROLACTAM;3-AMINOHEXAHYDRO-2H-AZEPIN-2-ONE;3-AMINO-AZEPAN-2-ONE;3-AMINO-2-AZEPANONE;(+/-)-ALPHA-AMINO-OMEGA-CAPROLACTAM;(+/-)-ALPHA-AMINO-EPSILON-CAPROLACTAM;DL-ALPHA-AMINO-EPSILON-CAPROLACTAM;DL-A-AMINO-E-CAPROLACTAM
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CAS No:
Description
The product has a purity of 97%, a melting point of 76°C aminoacetamide, and a boiling point of 168-172°C (1.73kPa).
ChEBI: 2-aminohexano-6-lactam is an amino acid amide obtained by the intramolecular condensation of the terminal amino group with the carboxy group in lysine. It is a member of caprolactams and an amino acid amide. It is functionally related to an epsilon-caprolactam.
Characteristics
55.1
-1.64
1.0±0.1 g/cm3
77°C
172 °C / 13mmHg
137°C
1.470
2-8°C
0.000446mmHg at 25°C
2-8°C
Safety Information
3
Xn
26
Xn
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
22-36/37/38-20/22
3-Amino-2-azepanone Use and Manufacturing
Using cyclohexene as raw material, it is obtained by addition, ammoniation and Beckman rearrangement. (1) Addition In the presence of liquid sulfur dioxide medium, cyclohexene reacts with nitrosyl chloride to obtain bis-(2-chloro-1-nitroso-cyclohexane). (2) Ammonification In the presence of a small amount of hexamethylenetetramine, bis-(2-chloro-1-nitroso-cyclohexane) reacts with liquid chlorine to obtain α-aminocyclohexanone oxime hydrochloride. (3) Beckman rearrangement In the presence of transposition agent chlorosulfonic acid and sulfuric acid, α-aminocyclohexanone oxime hydrochloride undergoes Beckman rearrangement reaction to obtain DL-aminocaprolactam.
L-lysine intermediate.
3-Aminoazepan-2-one is used in preparation of Triazolgoquinazolinamino Azepanones and Diazepanones as well as Triazoloquinazolinyl Amino Acid Amides as AHR inhibitors.