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FIAC

FIAC structure

CAS No:
69123-90-6
Formula:
C9H11FIN3O4
Chemical Name:
FIAC
Synonyms:
2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-;4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2(1H)-pyrimidinone;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine;1-β-D-2′-Fluoroarabino-5-iodocytosine;2′-Fluoro-5-iodo-1-β-D-arabinofuranosylcytosine;FIAC;Fiacitabine;FOAC;NSC 382097
Categories:
Biochemical Engineering > Saccharides

Description

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. IC50 value: 2.5/12.6 nM (HSV1/2) [2]Target: HSVFIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferatio

Fiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.|Fiacitabine is a pyrimidine nucleoside analog with activity against various herpesviruses. Fiacitabine is converted to its triphosphate form in vivo and inhibits viral DNA polymerase.

FIAC Basic Attributes

Molecular Weight：

371.1

Exact Mass：

371.10

UNII：

4058H365ZB

DSSTox ID：

DTXSID8057807

NCI Thesaurus Code：

C73202

Characteristics

PSA：

108

XLogP3：

-0.27

Density：

2.4±0.1 g/cm3

Boiling Point：

524.6±60.0 °C at 760 mmHg

Flash Point：

271.1±32.9 °C

Refractive Index：

1.791

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine

FIAC Use and Manufacturing

Antiviral.

Computed Properties

Molecular Weight:371.10
XLogP3:-0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:370.97783
Monoisotopic Mass:370.97783
Topological Polar Surface Area:108
Heavy Atom Count:18
Complexity:430
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

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Decarboxylated AdoMet Formula

22365-13-5
2′-Deoxy-6-thioinosine Formula

2239-64-7
Quercetin 3-glucuronide Formula

22688-79-5
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one Structure

22882-02-6
Sucrose Structure

57-50-1
What is C18Dihydroceramide

2304-80-5
What is [5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl adamantane-1-carboxylate

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Hot Searches: anisometropia; nitrohydrochloric acid; tell me the formula for nitrogen oxide; structural formula for adenosine.; ammonium phosphate formula; nitrite formula

Guide of FIAC

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

FIAC

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