2-Amino-5-bromonicotinaldehyde

PREPARATION 5 PREPARATION OF 5-BRO -3-YL)PYRIDIN-2 -AMINE A. To a solution of 2-aminopyridine-3-carbaldehyde (10.1 g, 81.0 mmol) in acetonitrile (150 mL) was added N-bromosuccinimide (15.1 g, 84.0 mmol). The resulting mixture was stirred at reflux for 2 hours. After cooled to room temperature, the reaction mixture was filtered. The collected solid was washed with methanol, and dried in vacuo to afford 2-amino-5-bromopyridine-3-carbaldehyde as a brown solid in 79percent yield (12.9 g). 1H NMR (400 MHz, CDC1General procedure: A mixture of 2-aminopyridine-3-carboxaldehyde (2.0 mmol), carbonyl compound (3.0 mmol) and NaHSO4-SiO2 (0.4g) were taken in 10 ml RB Flask. The reaction mixture was homogenized with the help of glass rod. The resulting mixture was stirred in an oil-bath (80 C) for the appropriate time (Table-3). After completion of the reaction, as monitored by TLC, the reaction mixture was cooled to room temp and EtOAc (40 ml) was added to it, stirred for 5 min and filtered. The solvent was evaporated and the crude product was purified by column chromatography on silica gel by eluting with EtOAc-n-hexane (2:8) and crystallization from hot ethanol afforded the corresponding pure 1, 8-naphthyridine derivatives.General procedure: A mixture of 2-aminopyridine-3-carboxaldehyde (2.0 mmol), carbonyl compound (3.0 mmol) and NaHSO4-SiO2 (0.4g) were taken in 10 ml RB Flask. The reaction mixture was homogenized with the help of glass rod. The resulting mixture was stirred in an oil-bath (80 C) for the appropriate time (Table-3). After completion of the reaction, as monitored by TLC, the reaction mixture was cooled to room temp and EtOAc (40 ml) was added to it, stirred for 5 min and filtered. The solvent was evaporated and the crude product was purified by column chromatography on silica gel by eluting with EtOAc-n-hexane (2:8) and crystallization from hot ethanol afforded the corresponding pure 1, 8-naphthyridine derivatives.General procedure: A mixture of 2-aminopyridine-3-carboxaldehyde (2.0 mmol), carbonyl compound (3.0 mmol) and NaHSO4-SiO2 (0.4g) were taken in 10 ml RB Flask. The reaction mixture was homogenized with the help of glass rod. The resulting mixture was stirred in an oil-bath (80 C) for the appropriate time (Table-3). After completion of the reaction, as monitored by TLC, the reaction mixture was cooled to room temp and EtOAc (40 ml) was added to it, stirred for 5 min and filtered. The solvent was evaporated and the crude product was purified by column chromatography on silica gel by eluting with EtOAc-n-hexane (2:8) and crystallization from hot ethanol afforded the corresponding pure 1, 8-naphthyridine derivatives.General procedure: A mixture of 2-aminopyridine-3-carboxaldehyde (2.0 mmol), carbonyl compound (3.0 mmol) and NaHSO4-SiO2 (0.4g) were taken in 10 ml RB Flask. The reaction mixture was homogenized with the help of glass rod. The resulting mixture was stirred in an oil-bath (80 C) for the appropriate time (Table-3). After completion of the reaction, as monitored by TLC, the reaction mixture was cooled to room temp and EtOAc (40 ml) was added to it, stirred for 5 min and filtered. The solvent was evaporated and the crude product was purified by column chromatography on silica gel by eluting with EtOAc-n-hexane (2:8) and crystallization from hot ethanol afforded the corresponding pure 1, 8-naphthyridine derivatives.To a stirred solution of

Molecular Weight:201.02
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:199.95853
Monoisotopic Mass:199.95853
Topological Polar Surface Area:56
Heavy Atom Count:10
Complexity:131
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes