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4-Amino-1,8-naphthalimide

4-Amino-1,8-naphthalimide structure

CAS No:
1742-95-6
Formula:
C12H8N2O2
Chemical Name:
4-Amino-1,8-naphthalimide
Synonyms:
1H-Benz[de]isoquinoline-1,3(2H)-dione,6-amino-;Naphthalimide,4-amino-;6-Amino-1H-benz[de]isoquinoline-1,3(2H)-dione;4-Amino-1,8-naphthalimide;4-Aminonaphthalimide;DFP 1;D 122;4ANI
Categories:
Cosmetic Ingredient > Hair Dyeing

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Description

orange amorphous powder

4-amino-1,8-naphthalimide is a benzoisoquinoline and a dicarboximide.

4-Amino-1,8-naphthalimide Basic Attributes

Molecular Weight：

212.2

Exact Mass：

212.20

EC Number：

217-110-1

DSSTox ID：

DTXSID6061941

HScode：

29251995

Characteristics

PSA：

72.2

XLogP3：

1.64270

Density：

1.105 g/mL at 25 °C(lit.)

Melting Point：

250 °C @ Solvent: Isopropanol

Boiling Point：

352.04°C (rough estimate)

Flash Point：

282.8ºC

Refractive Index：

1.6000 (estimate)

Water Solubility：

Soluble in DMSO

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39

RTECS Number：

DE4081000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (52%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 76 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES. (See all compounds classified as Poly(ADP-ribose) Polymerase Inhibitors.)

MeSH Entry Terms：

4-amino-1,8-naphthalimide

4-Amino-1,8-naphthalimide Use and Manufacturing

Uses

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

Manufacturing Info：

1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino-: ACTIVE

Computed Properties

Molecular Weight:212.20
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:212.058577502
Monoisotopic Mass:212.058577502
Topological Polar Surface Area:72.2
Heavy Atom Count:16
Complexity:342
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetic acid

Ammonia

Nitric acid

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Guide of 4-Amino-1,8-naphthalimide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Learn More Other Chemicals

4-Amino-1,8-naphthalimide

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