Acid Blue 1

566.66

566.152100

204-934-1

FH1929ICIT

1602

DTXSID3026065

VIOLET POWDER|Dark bluish-green powder

V - Various

32041200

137.41000

5.92380

Dark bluish-green to dark purple Crystalline Powder

>250°C

H2O: 1 g/20 mL (20 ºC)

Storage temperature: no restrictions.

Abdominal-mouse LD50: 3000 mg/kg; intravenous-mouse LD50: 1200 mg/kg

Combustible; Decomposes by heating to release toxic nitrogen oxides, ammonia, sodium oxide and sulfur oxide fumes

A 2% AQ SOLN SHOWED A DEPRESSION OF SURFACE TENSION OF WATER OF 38.5% @ 37 °C|DILUTE AQ SOLN ARE BLUE & TURN YELLOW UPON ADDITION OF CONCN HYDROCHLORIC ACID; IN ABSENCE OF STRONG ACID OR CAUSTIC THE BLUE COLOR IS STABLE OVER WIDE PH RANGE|C.I. Acid Blue 1 displays acid-base-indicator properties, turning orange in the presence of concentrated hydrochloric acid and deep blue when sodium hydroxide is added.

Water soluble.

Salts, Basic

NONH for all modes of transport

3

45

24/25-53-45

BP6830000

T

Warehouse ventilated, low temperature and dry

Stable. Incompatible with strong oxidizing agents.

P261, P264, P273, P280, P285, P302+P352, P304+P341, P305+P351+P338, P312, P321, P322, P332+P313, P337+P313, P342+P311, P362, P363, P501

H312

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

NEWTON DW ET AL; EVALUATION OF PREPN OF PATENT BLUE (ALPHAZURINE 2G) DYE FOR PARENTERAL USE; AM J HOSP PHARM 32(SEPT) 912 (1975). PATENT BLUE DYE WAS STUDIED WITH REGARD TO MEDICATION ORDERS WHICH MAY BE PREPARED BY HOSPITAL PHARMACISTS.

Flash point data for this chemical are not available; it is probably combustible. (NTP, 1992)

Not Classified| |Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material may be controlled using a dry chemical, carbon dioxide, foam or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

CI ACID BLUE DYE (ORIGINATING FROM GERMICIDE BLOCKS IN TOILET RESERVOIRS) RECOVERED FROM FILTERED SEWAGE.

moderately toxic

C.I. Acid Blue 1's production and use as a dye for wool, silk, leather, and jute, as a paper stain, to color phenol-formaldehyde resins, milled soaps, inks, and casein, as a biological stain(1) and to color medicinal products(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(3), indicates that C.I. Acid Blue 1 will have very high mobility in soil(SRC). Due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(4,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(5,SRC), may slow down or prevent leaching(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization of this compound will not be important from moist soil surfaces(4,SRC).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(1), indicates that C.I. Acid Blue 1 should not adsorb to suspended solids and sediment in water(SRC). However, due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(3,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(4,SRC), may lead to increased adsorption on some surfaces(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization from water surfaces is not expected(3,SRC). According to a classification scheme(5), an estimated BCF value of 2(1,SRC), from a measured water solubility(2), suggests that bioconcentration in aquatic organisms is low(SRC).|ATMOSPHERIC FATE: The ionic state of C.I. Acid Blue 1 makes this compound essentially non-volatile(1,SRC); therefore, this compound should exist in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Acid Blue 1 may be physically removed from the air, mainly by wet deposition(SRC).

An estimated BCF value of 2 was calculated for C.I. Acid Blue 1(SRC), using a measured water solubility of 30,000 mg/l(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of C.I. Acid Blue 1 is estimated as approximately 15(SRC), using a measured water solubility of 30,000 mg/l(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that C.I. Acid Blue 1 has very high mobility in soil(SRC). Due to the ionic nature of the dye, the retention of C.I. Acid Blue 1 by ion-exchange processes(4,SRC), particularly on clay surfaces and adsorption at mineral surfaces such as geothite(5,SRC), may slow down or prevent leaching(SRC).

Since C.I. Acid Blue 1 is an ionic compound, volatilization from water and moist soil surfaces will not be important(1,SRC).

THE OCCURRENCE AND FATE OF TRIPHENYLMETHANE BLUE DYES INCLUDING PATENT BLUE V DYE IN THE AQUATIC ENVIRONMENT WERE STUDIED.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 62,878 workers (9626 of these are female) are potentially exposed to C.I. Acid Blue 1 in the US(1). Occupational exposure may be through inhalation of dusts and dermal contact with this compound at workplaces where C.I. Acid Blue 1 is produced or used(2,SRC). The general population may be exposed to C.I. Acid Blue 1 via ingestion of pharmaceuticals and dermal contact with products containing C.I. Acid Blue 1(SRC).

Dyes|EXPTL USE: THE BLUE TEST IS DESIGNED TO REVEAL EDEMA OF TOTAL OR PARTIAL LYMPHATIC ORIGIN. INTOLERANCE TO THE DYE INJECTED IS RARE, THOUGH SOMETIMES SEVERE, & USERS SHOULD BY AWARE OF THE POSSIBILITY.

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)

IT IS OF SOME INTEREST THAT SEVERAL DYES RELATED TO PARAROSANILINE, WHICH INCLUDES BLUE VRS, EXHIBIT GENOTOXICITY & THAT THIS ACTIVITY IS CORRELATED WITH THE PRESENCE OF A SUBSTITUTED OR UNSUBSTITUTED AMINO GROUP AT THE R3 POSITION PARA TO THE N+ AMINO GROUP. THUS PATENT BLUE IS INACTIVE. THIS DYE INSTEAD HAS SULFONIC GROUPS IN THIS POSITION WHICH MAY INTERFERE WITH ACTIVATION AT THE N+ ATOM.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

DRUG HYPERSENSITIVITY ON PATIENTS BEING TESTED BY SKIN-PRICK & RECEIVING LYMPHOGRAM.|A CASE OF AN ALLERGIC REACTION TO PATENT BLUE VIOLET DYE USED FOR THE PURPOSE OF LYMPHANGIOGRAPHY IS REPORTED. SYMPTOMS WERE URTICARIAL REACTION, EDEMA OF THE EYELIDS & LIPS, AND HYPOTENSION.|Immediate reactions to patent blue dye /is presented/.|sensitivity to patent blue dye during skin prick testing and lymphography. A retrospective and prospective study.|For more Human Toxicity Excerpts (Complete) data for C.I. FOOD BLUE 3 (7 total), please visit the HSDB record page.

(4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadien-1-ylidene)diethylammonium hydroxide inner salt sodium salt

A grade of C.I. Acid Blue 1 produced in the UK has the following specifications: dye content, 82% min.; volatile matter (at 135 °C), 6% max.; water-insoluble matter, 0.2% max.; subsidiary dye content, 5% max.; sodium chloride and sulfate, 10% max.; arsenic, 1 mg/kg; lead, 10 mg/kg; copper, 10 mg/kg; chromium, 20 mg/kg.

Ethanaminium, N-[4-[[4-(diethylamino)phenyl](2,4-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, inner salt, sodium salt (1:1): ACTIVE|PHYSICOCHEMICAL DATA FOR PATENT BLUE VIOLET (PATENT BLUE V) DYE IN VARIOUS AQ & ORGANIC SOLVENTS.|OFFICIAL IN THE BRITISH PHARMACEUTICAL CODEX. A STOCK SOLN CONTAINING 0.06% GIVES A SUITABLE BLUE COLOR IN A CONCN OF 15 ML/L. TO OBTAIN A GREEN STOCK SOLN MIX 0.3% SULPHAN BLUE WITH 0.3% TARTRAZINE IN WATER.|BLUE VRS WAS USED IN THE PAST AS A FOOD DYE; HOWEVER, IT DOES NOT APPEAR ON ANY CURRENT LISTS OF DYES PERMITTED FOR USE IN FOOD IN US, JAPAN OR EUROPEAN ECONOMIC COMMUNITIES. IT IS PROVISIONALLY ACCEPTED FOR USE IN COSMETICS IN WHICH IT DOES NOT COME INTO CONTACT WITH MUCOUS MEMBRANES.|STUDY WAS CONDUCTED TO SUGGEST ADDITIONAL INDICATOR SUBSTANCES FOR THE TECHNIQUE OF ANGIOGRAPHY OF THE RETINAL AND CHOROIDAL VASCULATURES. CONCLUSION WAS THAT PATENT BLUE VF IS PROMISING SINCE ITS LD50 EXCEEDS 1000 MG/KG.

THE PURITY OF BATCHES OF COMMERCIAL DYES, INCL BLUE VRS, HAS BEEN EVALUATED BY THIN-LAYER CHROMATOGRAPHY AND NUCLEAR MAGNETIC RESONANCE SPECTROMETRY.|COLORED PAPER NAPKINS AND TOILET PAPER WERE EXTRACTED AND PATENT BLUE V WAS DETECTED BY CHROMATOGRAPHY AND SPECTROPHOTOMETRY.|IDENTIFICATION OF FOOD DYES VIA THIN-LAYER, PAPER & HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.

Food Additives -> COLOUR; -> JECFA Functional Classes|Cosmetics -> Cosmetic colorant; Hair dyeing

Food Additives -> COLOUR;