Azapropazone
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Azapropazone
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CAS No:
22304-30-9
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Formula:
C16H24N4O4
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Chemical Name:
Azapropazone
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Synonyms:
1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine dihydrate;1H-Pyrazolo(1,2-A)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, dihydrate;3-Dimethylamino-7-methyl-1,2-(N-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrate;Apazone dihydrate;Azapropazon dihydrat;Azapropazon dihydrat [german];Prolixan
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CAS No:
Description
An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
Characteristics
58.2
247-248°
Oral-rat LD50: 1950 mg/kg; Oral-Mouse LD50: 1080 mg/kg
Flammable; burning produces toxic nitrogen oxide fumes
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione
Computed Properties
Molecular Weight:336.39
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:336.17975526
Monoisotopic Mass:336.17975526
Topological Polar Surface Area:58.2
Heavy Atom Count:24
Complexity:516
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes