Azapropazone
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Azapropazone
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CAS No:
13539-59-8
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Formula:
C16H20N4O2
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Chemical Name:
Azapropazone
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Synonyms:
1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione,5-(dimethylamino)-9-methyl-2-propyl-;5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione;Cinnopropazone;Apazone;Azapropazone;Mi 85;3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine;Cinnamin;Prolixan;Sinnamin;AHR 3018;NSC 102824;27769-36-4
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CAS No:
Description
Nearly colorless, crystalline solid.ChEBI: A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group o propylmalonic acid.
Apazone is a member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid. It has a role as a uricosuric drug and a non-steroidal anti-inflammatory drug. It derives from a hydride of a 1,2,4-benzotriazine.|An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
Azapropazone Basic Attributes
300.36
300.36
236-913-8
102824
DTXSID6045408
M - Musculo-skeletal system
Characteristics
56.2
1.72
1.0975 (rough estimate)
247 °C
441.59°C (rough estimate)
218.7±26.8 °C
1.6000 (estimate)
Oral-rat LD50: 1800 mg/kg; Oral-Mouse LD50: 1080 mg/kg
Flammable; burning produces toxic nitrogen oxide fumes
169.5 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)
5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione
Azapropazone Use and Manufacturing
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
Pharmaceuticals
Computed Properties
Molecular Weight:300.36
XLogP3:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:300.15862589
Monoisotopic Mass:300.15862589
Topological Polar Surface Area:56.2
Heavy Atom Count:22
Complexity:516
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes