(S)-2-(Aminomethyl)-1-Cbz-pyrrolidine

General procedure: To a stirred soln of azide derivative 9a or 9b (4.03 mmol) in THF (1 mL) was added solid Ph3P (4.03 mmol) and H2O (6.04 mmol). The resulting solution was stirred for 12 h at r.t., then concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel (MeOH–CH2Cl2, 9:1).A typical procedure for the reduction is as follows: starting with a solution of (S)-2-carbamoyl-l-7V-CBz-pyrrolidine (0.5g, 2mmol) in THF (10ml), borane BHGeneral procedure: To a stirred soln of azide derivative 9a or 9b (4.03 mmol) in THF (1 mL) was added solid Ph3P (4.03 mmol) and H2O (6.04 mmol). The resulting solution was stirred for 12 h at r.t., then concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel (MeOH–CH2Cl2, 9:1).A typical procedure for the reduction is as follows: starting with a solution of (S)-2-carbamoyl-l-7V-CBz-pyrrolidine (0.5g, 2mmol) in THF (10ml), borane BH

Molecular Weight:234.29
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:234.136827821
Monoisotopic Mass:234.136827821
Topological Polar Surface Area:55.6
Heavy Atom Count:17
Complexity:252
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes